Background: As the third leading cause of death, cancers have a special place in the Iranian health system. Several studies have been done in some regions of the country with few years of follow-ups, but this was the first standardized study to investigate the incidence trends of colorectal cancer in Iran in a one-decade period.   Methods: The registered data for colorectal cancer cases...

Colorectal cancer remains one of the major cancer- related deaths despite progress in the treatment during past decades. Detection of disease at earlier stages reduces its mortality. The aim of current study was to investigate expression of Cytokeratin 19 (CK19), Cytokeratin 20 (CK20) and Guanylyl Cyclase C (GCC) mRNA in peripheral blood of non- metastatic colorectal cancer patients which may r...

background:the present study compared the differences between survivals of patients with colorectal cancer according to their ethnicity adjusted for other predictors of survival. methods: in this prospective cohort study patients were followed up from definite diagnosis of colorectal cancer to death. totally, 2431 person-year follow-ups were undertaken for 1127 colorectal cancer patients once e...

introduction: detection of malignant cells in the peritoneal cavity indicates the extension of cancer cells. the aim of this study is to evaluate the incidence rate of positive cytology in colorectal cancer and its relationship with the local progress of the tumor.  methods: in a 2-year prospective study in mashhad and iran universities of medical sciences, peritoneal lavage was performed on 40...

colorectal cancer (crc) is a third most common epithelial carcinoma. crc is known to develop from the early precancerous lesion to full blown malignancy via definite phases due to cumulative mutations and aberrant methylation of number of genes. the use of serum biomarkers that is non-invasive to discriminate cancer patients from healthy persons will prove to be an important tool to improve the...

abstract:   introduction: colorectal cancer (crc) is one of the most common cancers in the world. during the past decades, survival of colorectal cancer patients has improved worldwide, however, it is not clear what factors have contributed to this development. this study was designed to evaluate the prognostic impact of a wide spectrum of pathologic parameters on survival rate in patients with...

background: mucinous adenocarcinoma colorectal cancer present at a more colorectal advanced stage of disease and showe a poorer prognosis than those with other types of carcinoma. the purpose of the present study was to clarify the clinicopathological characteristics of mucinous colorectal carcinoma in the iranian population. methods: 110 patients with mucinous adenocarcinoma were selected from...

primula auriculata (tootia) is one of the most important local medicinal plants in hamedan district, iran. to investigate cytotoxicity and apoptosis induction of crude methanolic extract and different fraction of it we compared several methods on ht-29 human colon adenocarcinoma cells. cancer cell proliferation was measured by 3-(4, 5‑dimethylthiazolyl)-2, 5‑diphenyl‑tetrazolium bromide (mtt) a...