objective: depression is a major health problem, which is not only underrecognized and undertreated, but is also associated with significant morbidity and mortality. it has been suggested that combination therapy rapidly reduces depressive symptoms in patients with moderate to severe depression and is more effective than monotherapy; but this suggestion remains controversial. serotonergic and n...

objective: the protective effect of silymarin (smn) on mycophenolate mofetil (mmf)–induced duodenal disorders was investigated. materials and methods: forty-two wistar rats were assigned to seven groups including control and test groups. the control animals received saline and the test animals were treated with mmf (30 mg/kg, orally) and saline, mmf and smn (25, 50, and 100 mg/kg, orally), mmf ...

objective: the fact that some antidepressants with strong effects on serotonin reuptake blockade fail to relieve obsessive-compulsive symptoms has caused growing interest in investigating noradrenergic function in obsessive-compulsive disorder (ocd) . in light of the above, we undertook a trial to investigate whether the combination of citalopram with nortriptyline is more effective in treating...

Repositioning of approved drugs has recently gained new momentum for rapid identification and development of new therapeutics for diseases that lack effective drug treatment. Reported repurposing screens have increased dramatically in number in the past five years. However, many newly identified compounds have low potency; this limits their immediate clinical applications because the known, tol...