more recently medical chemistry research has been focused on proteins that drive and controlcell cycle progression. among them, the cyclin dependent kinases (cdk’s) are a group ofserine/threonine kinases, which rule the transition between successive stages of the cell cycle. theactivity of cdk’s is regulated by multiple mechanisms, including binding to cyclins, which is a broadclass of positive...

The nucleophilic substitution of alkyl fluorides was achieved in the intramolecular reactions with O- and N-nucleophiles. The intramolecular defluorinative cyclization reaction was influenced by the nature of nucleophiles, the size of the ring to be formed, and the comformational rigidity of the precursors. Intermolecular nucleophilic substitution reactions of alkyl fluorides under similar reac...

Fast methods for volume based Protein-Protein docking exist (eg. [1] or [4]). However, they employ the rigid-body assumption, and often miss the correct solution. To enhance todays docking algorithms the "induced fit" (comformational changes of a protein during the docking process) must be handled. Flexibility studies can help improving docking algorithms. Flexibility can be considered by enume...