نتایج جستجو برای: conditioned medium

تعداد نتایج: 259755  

Journal: :American journal of physiology. Cell physiology 2000
S Fischer M Wobben J Kleinstück D Renz W Schaper

An in vitro model of the blood-brain barrier (BBB), consisting of porcine brain-derived microvascular endothelial cells (PBMEC), was used to evaluate the effect of astrocytes in the BBB disruption during hypoxia. Hypoxia-induced hyperpermeability was decreased significantly in a coculture model of astroglia cells, either astrocytes or C6 glioma cells, with PBMEC and, to the same extent, when gl...

2014
Paul J Mintz Kai-Wen Huang Vikash Reebye Georgios Nteliopoulos Hong-Shiee Lai Pal Sætrom Noriyuki Kasahara Steen Jensen Madhava Pai Myrtle YA Gordon Stephen B Marley Rosemary Behan Duncan R Spalding Abdelali Haoudi Mohamed M Emara Joanna Nicholls John J Rossi Nagy A Habib

Despite the progress in our understanding of genes essential for stem cell regulation and development, little is known about the factors secreted by stem cells and their effect on tissue regeneration. In particular, the factors secreted by human CD34+ cells remain to be elucidated. We have approached this challenge by performing a cytokine/growth factor microarray analysis of secreted soluble f...

2014
Jianli Zhang Fujun Guo Jianqiang Mi Zhiye Zhang

OBJECTIVES Temporomandibular joint (TMJ) disorders are common disease in maxillofacial surgery. The aim of this study is to regenerate fibrocartilage with a mixture of TMJ fibrochondrocytes and periodontal ligament derived mesenchymal stem cells (PD-MSCs). MATERIALS AND METHODS Fibrochondrocytes and PD-MSC were cocultured (ratio 1 : 1) for 3 weeks. Histology and glycosaminoglycans (GAGs) assa...

2017
Emarndeena H Cheteh Martin Augsten Helene Rundqvist Julie Bianchi Victoria Sarne Lars Egevad Vladimir JN Bykov Arne Östman Klas G Wiman

Drug resistance is a major problem in cancer therapy. A growing body of evidence demonstrates that the tumor microenvironment, including cancer-associated fibroblasts (CAFs), can modulate drug sensitivity in tumor cells. We examined the effect of primary human CAFs on p53 induction and cell viability in prostate cancer cells on treatment with chemotherapeutic drugs. Co-culture with prostate CAF...

2018
Emi Okada Hidemi Nakata Maiko Yamamoto Shohei Kasugai Shinji Kuroda

Bisphosphonates impair function of osteoclasts and prevent bone resorption, the mechanism of which has been studied extensively. However, the possible effects of bisphosphonates on chondroblast differentiation and calcium deposition by osteoblasts have only been demonstrated recently. Moreover, cells from monocytic lineage are capable of stimulating osteoblast proliferation. Hence, susceptibili...

Journal: :Journal of dental research 2002
H Arzate L F Jiménez-García M A Alvarez-Pérez A Landa I Bar-Kana S Pitaru

Little is known about the molecular mechanisms that regulate the cementogenesis process, because specific cementum markers are not yet available. To investigate whether a cementoblastoma-conditioned medium-derived protein (CP) could be useful as a cementum biological marker, we studied its expression and distribution in human periodontal tissues, human periodontal ligament, alveolar bone, and c...

Journal: :Reproductive biology 2011
Malgorzata Duda Malgorzata Knet Zbigniew Tabarowski Maria Slomczynska

The purpose of the study was to examine the effect of luteal macrophage conditioned medium (LMCM) on progesterone and estradiol production by cultured granulosa cells. Porcine granulosa cells were cultured for 48 h with or without LMCM in the absence or presence of 100 ng/ml LH, FSH or prolactin. Progesterone and estradiol concentrations were measured by radioimmunoassay. Granulosa cells were a...

Hadi Pasdarshahri Moien Farmahini-Farahani

In this paper, exergy of conditioned air, exergy efficiency, irreversibility, and entropy generation of common models of evaporative cooling have been investigated in five cities of Iran. Direct evaporative cooling (DEC), indirect evaporative cooling (IEC), and two-stage IEC/DEC as the most popular methods of cooling have been modeled. Atmospheric conditions are considered as the dead state of ...

ژورنال: پوست و زیبایی 2012
اقدمی, ناصر, عبدل‌تهرانی, حسین, ملک‌محمدی, منا,

Background and Aim: Synthesis of extracellular matrix (ECM) is a key factor in wound healing. The predominant component of ECM is hyaluronic acid (HA). Recent studies have shown that adipose derived stem cell-conditioned medium (ADSC-CM) can increase the expression and synthesis of collagen I, III and fibronectin which are the components of ECM. The purpose of this study was to investigate the ...

Journal: :Cancer research 2008
Asya Varshavsky Ofra Kessler Sivan Abramovitch Boaz Kigel Shelly Zaffryar Gal Akiri Gera Neufeld

Semaphorin-3B (sema3B) and semaphorin-3F (sema3F) are secreted tumor suppressors of lung cancer. Sema3F functions as an antiangiogenic factor that repels endothelial cells and compromises their proliferation/survival. However, tumor cells expressing either endogenous or recombinant sema3B fail to repel endothelial cells efficiently. Sema3B found in the conditioned medium of such cells is almost...

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