نتایج جستجو برای: conditioned medium

تعداد نتایج: 259755  

Journal: :The Journal of biological chemistry 2013
Yanling Hu Amos C Hung Hao Cui Edgar Dawkins Marta Bolós Lisa Foa Kaylene M Young David H Small

The amyloid precursor protein (APP) is well studied for its role in Alzheimer disease. However, little is known about its normal function. In this study, we examined the role of APP in neural stem/progenitor cell (NSPC) proliferation. NSPCs derived from APP-overexpressing Tg2576 transgenic mice proliferated more rapidly than NSPCs from the corresponding background strain (C57Bl/6xSJL) wild-type...

Journal: :Blood 1977
A W Burgess E M Wilson D Metcalf

Medium conditioned by human placental tissue was found to stimulate granulocytic and monocytic colony formation by human marrow cells in semisolid agar cultures. The colony-stimulating activity of unfractionated conditioned medium was equivalent to the activity of standard peripheral blood underlayers. Placentas were a reliable source of active material, and one placenta provided enough materia...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Mehreen Zaki Natalie Andrew Robert H Insall

Entamoeba histolytica cells, the cause of amoebic dysentery, are highly motile, and this motility is an essential feature of the pathogenesis and morbidity of amoebiasis. However, the control of E. histolytica motility within the gut and during invasion is poorly understood. We have used an improved chemotaxis assay to identify the key extracellular signals mediating Entamoeba chemotaxis. The d...

Journal: :Investigative ophthalmology & visual science 1989
J Tombran-Tink L V Johnson

Tumor cells can be induced to differentiate in vitro by biochemical manipulation of their culture environment. In the studies described here, the effects of medium conditioned by human retinal pigmented epithelial (RPE) cells on Y79 human retinoblastoma cells have been examined. RPE-conditioned medium in conjunction with laminin and a poly-D-lysine substratum is observed to induce neuronal diff...

Bahareh Sadegh Tabrizi , Behrooz Johari, Faezeh Maghsood, Majid Lotfinia, Mehdi Kadivar, Nastaran Mohammadi Ghahhari, Sara Parsania, Shirin Lak,

Background: Mesenchymal stem cells (MSCs) are important candidates for MSC-based cellular therapy. Current paradigm states that MSCs support local progenitor cells in damaged tissue through paracrine signaling. Therefore, study of paracrine effects and secretome of MSCs could lead to the appreciation of mechanisms and molecules associated with the therapeutic effects of these cells. This study ...

Journal: :The Journal of clinical investigation 1985
K S Zuckerman G C Bagby E McCall B Sparks J Wells V Patel D Goodrum

Conditioned media were prepared from human peripheral blood monocytes and human umbilical vein endothelial cells. These media were assayed for erythroid burst-promoting activity (BPA) using human peripheral blood monocyte-depleted mononuclear cells as targets and assessing the stimulatory effect of the conditioned media on growth of early erythroid progenitor cells. Both monocytes and endotheli...

2016
Steven Roth John C. Dreixler Biji Mathew Irina Balyasnikova Jacob R. Mann Venkat Boddapati Lai Xue Maciej S. Lesniak

PURPOSE We have previously demonstrated the protective effect of bone marrow stem cell (BMSC)-conditioned medium in retinal ischemic injury. We hypothesized here that hypoxic preconditioning of stem cells significantly enhances the neuroprotective effect of the conditioned medium and thereby augments the protective effect in ischemic retina. METHODS Rats were subjected to retinal ischemia by ...

2014
Biao Sun Shilei Guo Fei Xu Bin Wang Xiujuan Liu Yuanyuan Zhang Yan Xu

In recent years, the bioactive factors were utilized in exercise and athletic skin injuries. In this research, the concentrated conditioned medium of hypoxia-preconditioned adipose mesenchymal stem cells, which is rich in bioactive factor, is applied in full-thickness skin defect model to evaluate the therapeutic efficacy. Adipose mesenchymal stem cells were harvested from the abdominal subcuta...

2015
Darren A. Yuen David M. Kepecs Yanling Zhang Suzanne Advani Kerri Thai Kim A. Connelly Richard E. Gilbert

BACKGROUND Bone marrow-derived early outgrowth cells (EOCs) secrete soluble factors that exert potent renoprotective effects, such that infusion of their conditioned medium recapitulates the affects of the cells themselves. OBJECTIVES The objective of this study is to test whether the protective effect of conditioned medium infusion wanes with time and whether tachyphylaxis occurs with repeat...

Journal: :Molecular cancer research : MCR 2009
Steffen E Schnitzer Andreas Weigert Jie Zhou Bernhard Brüne

Hypoxia and signaling via hypoxia-inducible factor-1 (HIF-1) is a key feature of solid tumors and is related to tumor progression as well as treatment failure. Although it is generally accepted that HIF-1 provokes tumor cell survival and induces chemoresistance under hypoxia, HIF-1-independent mechanisms operate as well. We present evidence that conditioned medium obtained from A549 cells, incu...

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