نتایج جستجو برای: conformational changes

تعداد نتایج: 897581  

Journal: :biomacromolecular journal 2015
aghdas banaei hedayatollah ghorchian reza faraji dana ali akbar moosavi–movahedi

the effects of electromagnetic fields (emfs) radiation at the frequency of 940 mhz on the structure and function of human adult and fetal hemoglobin (hba and hbf) were studied. after extraction and purification of hba and hbf, the oxygen absorption values for exposed and unexposed hba and hbf to emf were compared. the slope of oxygen absorption curve for exposed hba was increased while that for...

Journal: :journal of paramedical sciences 0
mona zamanian-azodi proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran mohammad esmaeil akbari cancer research center, shahid beheshti university of medical sciences, tehran hamidreza khademi dept. of biology, science and research branch, islamic azad university, tehran

albumin has a fundamental role in human body. its main tasks in blood are to regulate osmotic blood pressure, maintaining the ph, and transporting metabolites and drugs throughout the vascular system.  pharmacological studies of the interaction of drugs on hsa are important due to structural and functional changes of this vital protein; thus, here in this research the effect of valproate as a c...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Zhou Fan Ron O Dror Thomas J Mildorf Stefano Piana David E Shaw

Research on change-point detection, the classical problem of detecting abrupt changes in sequential data, has focused predominantly on datasets with a single observable. A growing number of time series datasets, however, involve many observables, often with the property that a given change typically affects only a few of the observables. We introduce a general statistical method that, given man...

1999
Qingling Yang Margaret A. Gidney Harold J. Jennings Wei Zou Roger Mackenzie Lina Thérien Tomoko Hirama

Journal: :Biophysical Journal 2018

L. Bejjit M. Bouachrine M. Haddad M. Hamidi Z. El Malki

In this paper we report on a combination of experimental and theoretical study of a new copolymer based on carbazole and methylthiophene (Cbz-Mth), in their neutral and oxidized states. We discuss the influence of chain length on conformational and optoelectronic properties with the DFT method. Conformational analysis shows that there are no big changes in the structural parameters of neutral o...

The surface parameter of nanoparticles such as hydrophobicity and a hydrophilicity on protein structure and function is very important. In this study, conformational changes of glucose oxidase (GOx) in the mercaptopurine: GNPs and 11-mercaptoundecanoic acid: GNPs as a hydrophobic and a hydrophilic GNPs surface was investigated by various spectroscopic techniques, including: UV-Vis absorption, f...

Journal: :iranian journal of pharmaceutical research 0
m rzaei-tavirani sh moghaddamnia b ranjbar s namaki p zolfaghari

thermal conformational changes in human serum albumin (hsa) in present with a 10 mm phosphate buffer, at ph=7 have been investigated via circular dichroism (cd) and uv spectroscopic methods. the results indicate that temperature in a range of 25oc to 55oc could induce a reversible conformational change in the structure of hsa. the hsa phase transition corresponds to the physiological and pathol...

B Ranjbar M Rzaei-Tavirani P Zolfaghari S Namaki SH Moghaddamnia

Thermal conformational changes in human serum albumin (HSA) in present with a 10 mM phosphate buffer, at pH=7 have been investigated via circular dichroism (CD) and UV spectroscopic methods. The results indicate that temperature in a range of 25oC to 55oC could induce a reversible conformational change in the structure of HSA. The HSA phase transition corresponds to the physiological and patho...

The surface parameter of nanoparticles such as hydrophobicity and a hydrophilicity on protein structure and function is very important. In this study, conformational changes of glucose oxidase (GOx) in the mercaptopurine: GNPs and 11-mercaptoundecanoic acid: GNPs as a hydrophobic and a hydrophilic GNPs surface was investigated by various spectroscopic techniques, including: UV-Vis absorption, f...

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