INTRODUCTION Approximately a third of the population worldwide is chronically infected with Toxoplasma gondii. Pyrimethamine-based regimens are recommended for the treatment of toxoplasmosis. OBJECTIVE The aim was to evaluate the safety profile of pyrimethamine-based treatment for the three main Toxoplasma manifestations: toxoplasmic encephalitis (TE), ocular toxoplasmosis, and congenital tox...

Toxoplasma gondii is a protozoan parasite infecting up to one third of the world's population. T. gondii infection is usually benign in immunocompetent patients but can be life-threatening when congenitally transmitted. Congenital toxoplasmosis presentation ranges from severe central nervous system and ocular features, to a well appearing newborn with onset of complications late in childhood. T...

Congenital toxoplasmosis is an established cause of abortion, neonatal disease and ocular defects presenting in later life. Preventative options include health education, immunization and screening of pregnant women and infants with appropriate management of cases found to be at risk. Screening requires a knowledge of the disease, the test, the treatment and the administration of the proposed p...

Toxoplasmosis is a systemic infection caused by the protozoan parasite Toxoplasma gondii, which is transmitted through the ingestionofcontaminated food. Less frequently, toxoplasmosis is acquired by blood transfusion or an organ transplant. Congenital toxoplasmosis, which is caused by vertical transmission from the mother to the fetus, has an estimated prevalence of 20% of infected mothers tran...

INTRODUCTION There is a paucity of data on the occurrence of congenital toxoplasmosis in children born to mothers dually infected with HIV and Toxoplasma gondii. OBJECTIVE To evaluate aspects of the mother-infant pairs associated with vertical transmission of toxoplasmosis in women co-infected with HIV in a referral center for perinatally acquired infections in Belo Horizonte, Brazil. METHO...

BACKGROUND Congenital toxoplasmosis can cause significant neurologic manifestations and other untoward sequelae. METHODS The Palo Alto Medical Foundation Toxoplasma Serology Laboratory database was searched for data on infants 0 to 180 days old, in whom congenital toxoplasmosis had been confirmed and who had been tested for Toxoplasma gondii-specific immunoglobulin G (IgG), IgM, and IgA antib...

The immunopathogenesis of toxoplasmosis during pregnancy is not completely understood. This paper will try to discuss the most frequently asked questions about the immunopathogeny of congenital toxoplasmosis: differential virulence of Toxoplasma isolates, genetic susceptibility to infection, facilitation of placental transfer, models of congenital toxoplasmosis, and transmission in seropositive...

conclusions there was high percentage of seronegative (70.65 %) igg and igm antibodies in full-term pregnant women. they were susceptible to acute toxoplasmosis; thus, prenatal screening was recommend in our province after cost-beneficial analyses. results the participants’ age range was 15 to 45 years (average: 27.4 ± 13). of the 501 pregnant women, 70.65 % (n = 354) were seronegative for t. g...