Inherited BRCA1/2 mutations confer elevated ovarian cancer risk. Knowledge of factors that can improve ovarian cancer risk assessment in BRCA1/2 mutation carriers is important because no effective early detection for ovarian cancers exists. A cohort of 1,575 BRCA1 and 856 BRCA2 mutation carriers was used to evaluate haplotypes at ATM, BARD1, BRIP1, CTIP, MRE11, NBS1, RAD50, RAD51, and TOPBP1 in...

PURPOSE OF REVIEW To provide an overview of the transplant component of the Canadian Organ Replacement Register (CORR). FINDINGS CORR is the national registry of organ failure in Canada. It has existed in some form since 1972 and currently houses data on patients with end-stage renal disease and solid organ transplants (kidney and/or non-kidney). The transplant component of CORR receives data...

Coronatine (COR) is a plasmid-encoded phytotoxin synthesized by several pathovars of phytopathogenic Pseudomonas syringae. The COR biosynthetic gene cluster in P. syringae pv. glycinea PG4180 is encoded by a 32-kb region which contains both the structural and regulatory genes needed for COR synthesis. The regulatory region contains three genes: corP, corS, and corR. corS is thought to function ...

Table 1: Four simulation scenarios used in the evaluation of the bias-variance decomposition. The simulation scenarios are taken from Zou & Hastie (2005). scenario n p β Structure of X (1) 100 8 (3, 1.5, 0, 0, 2, 0, 0, 0) corr (i, j) = 0.5|i−j| (2) 100 8 0.85 for all j corr (i, j) = 0.5|i−j| (3) 50 40 βj = { 0 j = (1, . . . , 10, 21, . . . , 30) 1 j = (11, . . . , 20, 31, . . . , 40) corr (i, j...

The visual correspondence problem is a major issue in computer vision. Correlation is a common tool for this problem. Most classical correlation methods fail near the disparity discontinuities, which occur at the boundaries of objects. In this paper, a partial correlation technique is proposed to solve this problem. Robust location methods are used to perform this partial correlation. Compariso...

Premature degradation of CFTR F508 causes cystic fibrosis (CF). CFTR F508 folding defects are conditional and folding correctors are being developed as CF therapeutics. How the cellular environment impacts CFTR F508 folding efficiency and the identity of CFTR F508’s correctable folding defects is unclear. We report that inactivation of the RMA1 or CHIP ubiquitin ligase permits a pool of CFTR F5...

It is known that in the selected mapping (SLM) scheme for orthogonal frequency division multiplexing (OFDM), correlation (CORR) metric outperforms the peak-to-average power ratio (PAPR) metric in terms of bit error rate (BER) performance. It is also well known that four times oversampling is used for estimating the PAPR performance of continuous OFDM signal. In this paper, the oversampling effe...

In the present study, methanolic extracts of roots of Vitex negundo L. and extracts of leaves of Vitex negundo L., Ricinus communis L. and Aegle marmelos Corr. were explored for possible antifilarial effect against Brugia malayi microfilariae. It was observed that among the herbal extracts, root extract of Vitex negundo L. and leaves extract of Aegle marmelos Corr. at 100 ng/ml concentration sh...

Let k be a field of characteristic 0 and let Vk be the category of smooth projective varieties over k. By ∼ we denote an adequate equivalence relation for algebraic cycles on varieties [Ja00]. For every X ∈ Vk let A i ∼(X) = (Z (X)/ ∼)⊗Q be the Chow group of codimension i cycles on X modulo the chosen relation ∼ with coefficients in Q. Let X, Y ∈ Vk, let X = ∪Xi be the connected components of X...

Abstract Background The optimum lipid indexes, predicting the coronary lesion in postmenopausal women are not clear. Objective To evaluate predicter for routine and advanced tests. Method 300 were enrolled assigned into heart disease (CHD) Group (242), non-CHD (58). Routine indexes measured with standard laboratory test nuclear magnetic resonance (NMR) spectroscopy. correlation predictivities C...