Notch signaling pathway is involved in many physiological and pathological processes. The γ-secretase inhibitor DAPT inhibits Notch signaling pathway and promotes nerve regeneration after cerebral ischemia. However, neuroprotective effects of DAPT against acute craniocerebral injury remain unclear. In this study, we established rat model of acute craniocerebral injury, and found that with the i...

Microscopic features of primary and secondary hemorrhages in the stem portion of the brain in craniocerebral injuries are described. Criteria of differential diagnosis between primary and secondary hemorrhages in the stem in subjects dead during 24 h after isolated and combined craniocerebral injuries are defined. The forensic medical significance of differential diagnosis of hemorrhages in the...

AIM To assess the importance of the first aid and medical care administered on the battlefield and at a field surgical unit for the outcome of craniocerebral war injuries. METHODS State of consciousness of 38 persons with craniocerebral injuries was assessed by the Glasgow Coma Scale (GCS), and follow-up of the vital signs and neurological deficit were determined by GCS outcome scale. RESUL...

Hypernatremia is a common complication following craniocerebral injury and an independent predictor of mortality. To evaluate Association between total input fluid volume and the prognosis of patients with craniocerebral injury combined with hypernatremia. The study retrospectively collected 90 patients with craniocerebral injury combined with hypernatremia. The basic information, clinical data...

AIM The current study aims to explore the clinical characteristics of craniocerebral firearm injury and to improve the diagnosis and treatment of this condition. MATERIAL AND METHODS Data from 56 patients with craniocerebral firearm injury were analyzed retrospectively for projectile types, traumatic conditions, and treatment approaches. RESULTS 43 patients exhibited intracranial foreign bo...

AIM To evaluate localization of certain zones of craniocerebral trauma and determine their importance for genesis ofposttraumatic epilepsy. PATIENTS AND METHODS Study encompassed 50 war veterans, with craniocerebral trauma and posttraumatic epilepsy. Control group included 50 war veterans, with war craniocerebral injury who have not experienced epileptic seizures. The craniocerebral trauma zo...

AIM To explore the causes of scalp wound infection, pathogen distribution, characteristics of antimicrobial susceptibility and therapeutic measures following craniocerebral trauma caused by the 2008 Wenchuan earthquake. MATERIAL and METHODS We retrospectively analyzed the microbiology records of patients admitted with craniocerebral trauma to the Department of Neurosurgery, We...

The aim of this study was to study the expression changes of neurite outgrowth inhibitor A (Nogo-A), Glial Fibrillary Acidic Protein (GFAP), and insulin-like growth factor 1 (IGF-1) in rat brain tissues after craniocerebral injury, and to investigate the neural repair mechanism of experimental craniocerebral injury in rats. The control group was only cut the top scalp and removed the skull, whi...

BACKGROUND Dexmedetomidine is a highly selective adrenergic receptor agonist, which has a dose-dependent sedative hypnotic effect. Furthermore, it also has pharmacological properties, and the ability to inhibit sympathetic activity and improve cardiovascular stability during an operation. However, its protective effect on patients with severe craniocerebral injury in the perioperative period re...