Introduction: In this study, two constituents of saffron stigma (crocin and safranal) were tested for possible cytotoxic and antitumoral activity using brine shrimp and potato disc assays. Methods: In the brine shrimp assay, three wells containing 10 nauplii were tested for each concentration. After 24h, the number of the nauplii was counted. To investigate the antimicrobial activity of safr...

ABSTRACT Introduction: Fatigue is a manifestation of sub-health status, which causes serious negative effects in daily life. The antioxidant properties crocin have been widely investigated many diseases. However, no correlation between and fatigue was reported. Objective: To verify the anti-fatigue efficacy swimming-induced exhaustive time. Materials Methods: In this study, mice were treated wi...

Objective(s): The objectives of the current study were to evaluate the effects of hepatic ‎ischemia/reperfusion (IR) injury on the activity of antioxidant enzymes, biochemical factors, and ‎histopathological changes in rat kidney, and to investigate the effect of crocin on IR-‎related changes. Materials and Methods: Thirty-two male Wistar rats were randomly allocated into four groups (n=8). The...

In this study, the effect of crocin, a substance found in Crocus sativus L. stigmata on nervous system development and regeneration was investigated. Crocin is a glycosyl ester of the polyene dicarboxylic acid crocetin and is one of the few families of carotenoids found in nature, which are freely soluble in water. In the first experiment, the effect of crocin (30 microM, 60 microM and 120 micr...

Objective: The present study was designed to investigate the putative antidepressant effects of crocin and crocetin, two major active ingredients of Crocus sativus L. (saffron) using mice in two different regimens of acute and sub-acute administration. Material and Methods: In acute treatment, antidepressant-like activities of crocin and crocetin (10, 20 and 40 mg/kg, i.p.) were evaluated using...

Crocin, a component of saffron, showed hypotensive which is perhaps due to vascular smooth muscle relaxant effect. The relaxant effects of saffron on tracheal smooth muscle also could be due to its constituent, crocin. In the present study, the relaxant effects of crocin and its possible mechanisms on rat tracheal smooth muscle were investigated. The relaxant effects of three cumulative concent...

The present study deals with the isolation of fourteen compounds from the active ethyl acetate (MPE) extract of M. pudica (L.) whole plant and their subsequent evaluation for the nitric oxide (NO), tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1ß) inhibitory activities in lipopolysaccharide (LPS) stimulated RAW 264.7 and J774A.1 cells. Among the tested compounds, L-mimosine (12...

Objective Crocin, a carotenoid isolated from Crocus sativus L. (saffron), is a pharmacologically active component of saffron. Nicotine consumption can decrease fertility in males through induction of oxidative stress and DNA damage. The aim of this study is to determine the effects of crocin on reproductive parameter damages in male mice exposed to nicotine. MaterialsAndMethods In this experime...

Saffron consists of bioactive compounds with health-promoting properties and is mainly used in medicine, flavoring coloring. In this study, we aimed to investigate the effect extraction methods on antioxidant activity saffron (Crocus sativus L.) extracts (SE) evaluate performance SE vegetable oils. stigmas were extracted water, ethanol, methanol, their combinations using maceration (ME), ultras...