objective: crocinisa saffron constituent with a potent anti-oxidant activity. the present study investigated the effects of crocin and insulin treatments (alone or in combination) on cardiac function and pathology in diabetic rats. materials and methods: diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (stz, 50 mg/kg). thereafter, crocin (5, 10 and 20 mg/kg, i.p.), sub...

objective(s): crocin is the chemical ingredient primarily responsible for the color of saffron. it has different pharmacological effects such as antioxidant, anticancer and memory improving activities. crocin tablets were evaluated for short-term safety and tolerability in healthy adult volunteers. materials and methods: the study was a randomized, double-blind, placebo-controlled design consis...

Saffron is considered as the most expensive spice in world. Due to low production, high demand and cost, saffron very prone adulteration for economic benefits while putting public health at risk. The significant characteristic determining quality of coloring strength (crocin content), which determined by measuring UV-Vis absorption 440 nm aqueous preparations this spice. Picrocrocin safranal ar...

Crocetin glycoside, crocin is a pharmacologically active component of Crocus sativus L. (saffron) that has been used in traditional Chinese medicine. Previously we demonstrated that crocin inhibited apoptosis in PC-I2 cells by affecting the function of tumor necrosis factor-α. In this study, we found that depriving cultured PC-12 cells of serum/glucose causes a rapid increase in cellular cerami...

background & aim: saffron is one of the expensive spices known since antiquity for its color, flavor and medicinal properties. saffron is the dried stigma of crocus sativus plant. the three basic components of the stigma on which the qualitative characteristics of saffron depend are crocin (color), picrocrocin (taste), and safranal (aroma). the quality of saffron is a function of climatic c...

Objectives: Crocin and safranal, the major constituents of saffron, exert neuroprotective effects. In the present study, we investigated the effects of crocin and safranal  (alone or in combination with insulin) on peripheral neuropathy in diabetic rats. Materials and Methods: Diabetes was induced by intraperitoneal (i.p.) injection of 60 mg/kg of streptozotocin (STZ) and confirmed by blood glu...

Objective(s):Acrylamide (ACR) has many applications in different industries. ACR damages the central and the peripheral nervous system in human and animals. Importance of ACR-induced neurotoxicity encouraged researchers to find both different mechanisms involved in ACR neurotoxicity and potent neuroprotective agents. Therefore, this study was designed to investigate the protective effect of cro...

Objective(s): Crocin is the chemical ingredient primarily responsible for the color of saffron. It has different pharmacological effects such as antioxidant, anticancer and memory improving activities. Crocin tablets were evaluated for short-term safety and tolerability in healthy adult volunteers. Materials and Methods: The study was a randomized, double-blind, placebo-controlled design consis...

Introduction: Muscular inflammation and atrophy is one of the characteristics of diabetes that causes motor disability in these individuals. Studies have shown that exercise training with different intensities and the use of herbal drugs can have favorable effects on diabetes. The aim of this study was to interactive effects of continuous and interval training with crocin consu...

Crocin, as a carotenoid compound of saffron, exerts a potent antioxidant property. Mesalazine is frequently used in the treatment of ulcerative colitis. This study investigated the effects of separated and combination treatments with crocin and mesalazine in a rat model of ulcerative colitis. Ulcerative colitis was induced by intra-colonic administration of acetic acid (4.00%, 1.00 mL) at 8 cm ...