SCOPE Curcumin revealed various health-beneficial properties in numerous studies. However its bioavailability is low due to its limited intestinal uptake and rapid metabolism. The aim of our project was to develop novel curcumin formulations with improved oral bioavailability and to study their safety as well as potential sex-differences. METHODS AND RESULTS In this crossover study, healthy s...

Malaria is a parasitic tropical disease that kills around 600,000 patients every year. The emergence of resistant Plasmodium falciparum parasites to artemisinin-based combination therapies (ACTs) represents a significant public health threat, indicating the urgent need for new effective compounds to reverse ACT resistance and cure the disease. For this, extensive curation and homogenization of ...

SUMMARY Curcuminoids, components of the rhizome of turmeric, show several beneficial biological activities, including anticarcinogenic, antioxidant, anti-inflammatory, and antitumor activities. Despite their numerous pharmaceutically important properties, the low natural abundance of curcuminoids represents a major drawback for their use as therapeutic agents. Therefore, they represent attracti...

Turmeric in Latin is Curcuma longa. Turmeric is the yellow spice that gives flavor to curried dishes. In the Far East, Turmeric is valued for more than just its culinary uses. The herb has been employed in the Ayurvedic healing tradition for centuries. The active ingredient in turmeric is the intense yellow pigment that is called curcumin. Curcumin is composed of three curcuminoids and is gener...

Curcuminoids refer to three main chemical substances, namely curcumin, demethoxycurcumin, and bis-demethoxycurcumin. These are used as natural coloring agents in some food products and have been reported to exhibit several biological activities in animal and human clinical studies. Due to its beneficial effects to human health, several analytical methods have been continuously proposed and deve...

P-type ATPases catalyze the active transport of cations and phospholipids across biological membranes. Members of this large family are involved in a range of fundamental cellular processes. To date, a substantial number of P-type ATPase inhibitors have been characterized, some of which are used as drugs. In this work a library of natural compounds was screened and we first identified curcumino...

Background: Curcuma longa is among the most commonly used spices in India and other Asian countries. The herb has also been used in Ayurveda and other traditional systems of medicine for the prevention and treatment of a variety of ailments. Curcuminoids are the major chemical constituents of C. longa that are of medicinal importance. Today, a large body of scientific evidence exists to indicat...