Turmeric (Curcuma domestica Val.) is a traditional Indonesian plant that has many benefits. Curcuminoids are turmeric compounds known to have effects as immunomodulators and been proven in several vivo tests. Immunosuppressive drugs such cyclophosphamide widely given improve clinical symptoms autoimmune patients cancer treatment which can cause susceptibility infection.Therefore,this study aime...

Turmeric (Curcuma longa) is an important condiment used in the culinary of several countries to spice and give a more intense yellow color food. The importance this root has gained attention due presence bioactive compounds known as curcuminoids (the main class phenolic found turmeric). health benefits attributed are mainly linked curcumin, major compound among curcuminoids. Scientific evidence...

PURPOSE To develop a bioanalytical assay using RP-HPLC to quantify the curcuminoid calebin A, to characterize its pharmacokinetics in rats after intravenous (IV) and oral (PO) administration, to identify its pharmacological activities and to evaluate its content in natural health products. METHODS An RP-HPLC method was developed for the detection of calebin A. Separation was carried out using...

Poly-herbals combination was applied to enhance biological activity, particularly antioxidant activity. This present study purposed assess the synergistic interaction of a five traditional Indonesian herbal plants through simultaneous and integrated statistical technique. The were extracted using maceration, purification conducted before extraction eliminate ballast compounds. A simplex ...

Aim: We report the synthesis and biological evaluation of a small library 15 functionalized 3-styryl-2-pyrazolines pyrazoles, derived from curcuminoids, as trypanosomicidal agents. Methods & results: The compounds were prepared via cyclization reaction between corresponding curcuminoids appropriate hydrazines. All derivatives synthesized investigated for their activities. Compounds 4a 4e sh...

Two turmeric food powders (C1 and C2) were studied for curcuminoid content their effects on the guinea pig intestinal tract in vitro. C1 contained a higher than C2 (5.22% vs 2.31%). increased gallbladder (∼10%) biliary smooth muscle tone (∼15%), without affecting sphincter of Oddi contractility. was more effective lowering ileum (–22% −37%), whereas reverse occurred colon (-50% −20%). Standard ...