Two new crystalline polymorphs and an amorphous phase of the active curcuminoid ingredient in turmeric are reported. Curcumin polymorph 2 has higher dissolution rate and better solubility than the known polymorph 1.

Abstract In this study, the effect of matrix compounds from natural curcuminoid resources on stability curcuminoids and emulsions thereof was evaluated. Curcuminoid were prepared rich sources (curcuminoid extract, an aqueous turmeric concentrate powder) with medium-chain triglyceride oil as lipid phase, lecithin, pectin emulsifiers. The exposed to light in visible wavelength range (300 nm–800 n...

Purpose Excessive production of parathyroid hormone-related protein (PTHrP) by tumor-like synoviocytes contributes to joint destruction in rheumatoid arthritis (RA). Having previously demonstrated that curcuminoid-only and essential oil-only fractions of turmeric prevent joint destruction in an animal model of RA, we hypothesized that synoviocyte PTHrP production could be one signaling pathway ...

A new strategy for the synthesis of curcuminoids is described involving the reaction of acetylacetone difluroboronite with an aromatic aldehyde in the presence of n-butylamine as catalyst. The new intermediate products, curcuminoid difluroboronites, of symmetrically substituted curcuminoids like curcumin and bisdemethoxycurcumin are stable, can be isolated and hydrolysed with aq. methanol at pH...

turmeric is an important herb used as medicines, turmeric is an important herb used as medicine, condiment and cosmetic. its main active compounds are curcuminoids and essential oils. the biomass production, essential oil composition and curcuminoid content of curcuma longa are known to be dependent on the growth and development conditions of rhizome. iran is a major importer of turmeric in the...

Herbs and herbal medicines are generally safe and effective against certain diseases. Generally, they are extensively used in Asian, African and other countries. Nowadays, they are gradually increasing the demand of consumption in Europe, America and other developed countries.1 Turmeric (Curcuma longa L.) is a well-known traditional herb that is considered to be useful as medicament for various...

With the purpose to improve the biological activities of curcumin, eight novel ferrocenyl curcuminoids were synthesized by covalent anchorage of three different ferrocenyl ligands. We evaluated their cytotoxicity on B16 melanoma cells and normal NIH 3T3 cells, their inhibition of tubulin polymerization and their effect on the morphology of endothelial cells. The presence of a ferrocenyl side ch...