The internal strain in cyclic amides are explained as a factor of resonance that are effected on the bond length C-N  and are a major factor of rates of hydrolysis. The cyclic amides in this study are optimized by Gaussian program and the bond length of C-N in the rings are studied by HF/6-31G*.

The internal strain in cyclic amides are explained as a factor of resonance that are effected on the bond length C-N  and are a major factor of rates of hydrolysis. The cyclic amides in this study are optimized by Gaussian program and the bond length of C-N in the rings are studied by HF/6-31G*.  

The internal strain in cyclic amides are explained as a factor of resonance that are effected on the bond length C-N and are a major factor of rates of hydrolysis. The cyclic amides in this study are optimized by Gaussian program and the bond length of C-N in the rings are studied by HF/6-31G*.

[reaction: see text] An efficient one-step amination of cyclic amides and ureas has been developed. Treatment of cyclic amides and cyclic ureas with BOP in the presence of DBU in various solvents led to the formation of cyclic amidines and cyclic guanidines in good to excellent yields. Concise syntheses of biologically intriguing kinetin and potent kinase inhibitor olomoucin were thus achieved ...

A novel amidase involved in bacterial cyclic imide metabolism was purified from Blastobacter sp. strain A17p-4. The enzyme physiologically functions in the second step of cyclic imide degradation, i.e., the hydrolysis of monoamidated dicarboxylates (half-amides) to dicarboxylates and ammonia. Enzyme production was enhanced by cyclic imides such as succinimide and glutarimide but not by amide co...

Chiral chelated lithium amides were designed and synthesized. Studies have been done to explore the use of these lithium amides or their corresponding amines for enantioselective reactions such as deprotonation of prochiral cyclic ketones, kinetic resolution of racemic 2-substituted cyclohexanones by deprotonation, regioselective deprotonation of optically active 3-keto steroids, alkylation of ...

A ruthenium-catalyzed C–H amidation using cyclic amides as directing groups features broad functional group tolerance. Mechanistic studies supported by DFT calculations highlight the relevance of six-membered ruthenacycles in catalytic cycle.

A copper-catalyzed method for the preparation of ynamides has been identified that proceeds via aerobic oxidative coupling of terminal alkynes with various nitrogen nucleophiles, including cyclic carbamates, amides and ureas, and N-alkyl-arylsulfonamides and indoles.

The reaction of N-acylaminoalkyl diethylacetals with triflic acid in benzene gave N-acylamino-diphenylalkyls. The proposed intermediates are the N-acyl-2-phenyl cyclic amides, which themselves are similarly converted to N-acylamino-diphenylalkyls.

The cyclic-imide-hydrolyzing activity of a prokaryotic cyclic-ureide-hydrolyzing enzyme, D-hydantoinase, was investigated. The enzyme hydrolyzed cyclic imides with bulky substituents such as 2-methylsuccinimide, 2-phenylsuccinimide, phthalimide, and 3,4-pyridine dicarboximide to the corresponding half-amides. However, simple cyclic imides without substituents, which are substrates of imidase (i...