نتایج جستجو برای: dact2

تعداد نتایج: 36  

2016
Meiying Zhang Enqiang Linghu Qimin Zhan Tao He Baoping Cao Malcolm V. Brock James G. Herman Rong Xiang Mingzhou Guo

Esophageal cancer is one of the most common malignancies worldwide. DACT2 is frequently methylated in human lung, hepatic, gastric and thyroid cancers. The methylation status and function of DACT2 remain to be elucidated in human esophageal cancer. Ten esophageal cancer cell lines, 42 cases of dysplasia and 126 cases of primary esophageal cancer samples were analyzed in this study. The expressi...

2013
Xiao Li Sergio Florez Jianbo Wang Huojun Cao Brad A. Amendt

Dact proteins belong to the Dapper/Frodo protein family and function as cytoplasmic attenuators in Wnt and TGFβ signaling. Previous studies show that Dact1 is a potent Wnt signaling inhibitor by promoting degradation of β-catenin. We report a new mechanism for Dact2 function as an inhibitor of the canonical Wnt signaling pathway by interacting with PITX2. PITX2 is a downstream transcription fac...

2014
Zhiyan Zhao James G. Herman Malcolm V. Brock Jindong Sheng Meiying Zhang Baoguo Liu Mingzhou Guo

Thyroid cancer is the most common endocrine malignant disease and the incidence is increasing. DACT2 was found frequently methylated in human lung cancer and hepatocellular carcinoma. To explore the epigenetic change and the role of DACT2 in thyroid cancer, 7 thyroid cancer cell lines, 10 cases of non-cancerous thyroid tissue samples and 99 cases of primary thyroid cancer samples were involved ...

2017
Ying Tan Qiu-Meng Li Ning Huang Si Cheng Guan-Jian Zhao Hong Chen Song Chen Zhao-Hua Tang Wen-Qian Zhang Qin Huang Yuan Cheng

DACT2, one of the Dact gene family members, was shown to function as a tumor suppressor. However, its function in gliomas remains largely unknown. In this study, we investigated the role of DACT2, underlying molecular mechanisms and its clinical significance in glioma patients. Downexpression of DACT2 in gliomas compared with adjacent normal brain tissues was correlated with glioma grade and po...

Journal: :American journal of cancer research 2014
Yuanzi Yu Wenji Yan Xuefeng Liu Yan Jia Baoping Cao Yingyan Yu Youyong Lv Malcolm V Brock Jame G Herman Julien Licchesi Yunsheng Yang Mingzhou Guo

Dapper, Dishevelled-associated antagonist of β-catenin (DACT), is a key regulator of Wnt signaling pathway. The purpose of this study is to explore the epigenetic changes and the function ofDACT2 in human gastric cancer (GC). Eight human gastric cancer cell lines, 167 cases of primary gastric cancer and 8 cases of normal gastric mucosa were involved in this study. In addition, methylation Speci...

2013
Sheng Gao Zhe Yang Zhi-Yun Zheng Jia Yao Feng Zhang Li-Ming Wu Hai-Yang Xie Lin zhou Shu-Sen Zheng

BACKGROUND Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies in humans, and its prognosis is generally poor even after surgery. Many advances have been made to understand the pathogenesis of HCC; however, the molecular mechanisms that lead to hepatocarcinogenesis and progression are still not clearly understood. METHODS The expression of DACT2 in specimens from 30 pair...

2016
Tingxiu Xiang Yichao Fan Chunhong Li Lili Li Ying Ying Junhao Mu Weiyan Peng Yixiao Feng Michael Oberst Kathleen Kelly Guosheng Ren Qian Tao

Wnt signaling plays an important role in breast carcinogenesis. DAPPER2 (DACT2) functions as an inhibitor of canonical Wnt signaling and plays distinct roles in different cell contexts, with its role in breast tumorigenesis unclear. We investigated DACT2 expression in breast cancer cell lines and primary tumors, as well as its functions and molecular mechanisms. Results showed that DACT2 expres...

Journal: :Cancer prevention research 2013
Jian Hou Lian-Di Liao Yang-Min Xie Fa-Min Zeng Xia Ji Bo Chen Li-Yan Li Meng-Xiao Zhu Cui-Xia Yang Qing-Zhao Tao Chen Xiu-E Xu Jian Shen Ming-Zhou Guo En-Min Li Li-Yan Xu

In animals ranging from fish to mice, the function of DACT2 as a negative regulator of the TGF-β/Nodal signal pathway is conserved in evolution, indicating that it might play an important role in human cancer. In this study, we showed that tumors with higher DACT2 protein level were correlated with better differentiation and better survival rate in patients with esophageal squamous cell carcino...

Journal: :American journal of physiology. Renal physiology 2010
Wen-Chin Lee Melinda T Hough Weijia Liu Robert Ekiert Nils O Lindström Peter Hohenstein Jamie A Davies

The overall pattern of the developing kidney is set in large part by the developing ureteric bud/collecting duct system, and dysgenesis of this system accounts for a variety of clinically significant renal diseases. Understanding how the behavior of cells in the developing ureteric bud/collecting duct is controlled is therefore important to understanding the normal and abnormal kidney. Dact pro...

Colorectal cancer (CRC) is one of the common causes of cancer death in Iranian population. Both genetic and epigenetic changes have been implicated in CRC pathogenesis. DACT2 gene as one of the WNT signaling pathway inhibitor was shown to display tumor suppressor activity in many cancers. The aim of present study was to investigate the methylation status of DACT2 gene and its ...

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