Background: The organochlorine DDT has estrogenic activity but the mechanism underlying the estrogenic activity of this pesticide remains unclear. In the present investigation here, we studied the transcriptional effects of a synthetic organochlorine pesticide o,p’-DDT [1.1.1.-trichloro-2-(o-chlorophenyl)-2-p-chloriphenyl ethane] and its metabolite p,p'-DDE (2-2-bis(4/chlorophenyl)-1-1-di...

This study was conducted to reveal the estrogenic effects of bisphenol A and o, p’-DDT on quailembryos. Thirteen fertilized eggs were used as control (injected with 20 μl corn oil), 15 eggs were injectedwith estradiol 17β (0.04 mg dissolved in 20 μl corn oil), 20 eggs were injected with BPA (2 mg dissolved in20 μl corn oil) and 20 eggs were injected with o, p’-DDT (2 mg dissolved in 20 μl corn ...

background: the organochlorine ddt has estrogenic activity but the mechanism underlying the estrogenic activity of this pesticide remains unclear. in the present investigation here, we studied the transcriptional effects of a synthetic organochlorine pesticide o,p’-ddt [1.1.1.-trichloro-2-(o-chlorophenyl)-2-p-chloriphenyl ethane] and its metabolite p,p'-dde (2-2-bis(4/chlorophenyl)-1-1-dic...

this study was conducted to reveal the estrogenic effects of bisphenol a and o, p’-ddt on quailembryos. thirteen fertilized eggs were used as control (injected with 20 μl corn oil), 15 eggs were injectedwith estradiol 17β (0.04 mg dissolved in 20 μl corn oil), 20 eggs were injected with bpa (2 mg dissolved in20 μl corn oil) and 20 eggs were injected with o, p’-ddt (2 mg dissolved in 20 μl corn ...

Previous work in our laboratory showed that o,p'-DDT increases the frequency of rat uterine contractions in vitro. The present study investigated whether this response was related to prostaglandin E 2 (PGE2) release from the uterine strips or to the estrogenicity of o,p'-DDT. Contraction frequency was evaluated by recording isometric spontaneous contractions in longitudinal uterine strips from ...

o,p'-DDT is an infamous xenoestrogen as well as a ubiquitous and persistent pollutant. Biomonitoring studies show that women have been internally exposed to o,p'-DDT at range of 0.3-500 ng/g (8.46×10(-10) M-1.41×10(-6) M) in blood and other tissues. However, very limited studies have investigated the biological effects and mechanism(s) of o,p'-DDT at levels equal to or lower than current exposu...

DDT was commercially introduced as an insecticide in the 1940s. Technical DDT contains 65 – 80 % p,p’-DDT. Other important constituents in the technical grade products are o,p’-DDT, p,p’-DDE and p,p’-DDD. The latter two compounds (along with their ortho, para analogues formed from o,p’-DDT) are also the major breakdown products in biological systems. Unless otherwise stated in this opinion, “DD...

Exposure to organochlorine pesticides, including DDT, has previously been associated with premature birth. Using an improved protocol to characterize dose and time dependent responses, the present report extends a preliminary finding by this laboratory that o,p'-DDT directly stimulates uterine contractility. Contraction frequency was determined in longitudinal uterine strips from pregnant rats ...