AIMS The aim of this study was to compare the efficacy and safety of valproate (Depakine-Chrono) versus placebo for the treatment of acute alcohol hallucinosis. METHODS 10 days' randomized, double-blind, parallel study was conducted; 40 patients with an ICD-10 diagnosis of acute alcohol hallucinosis were randomized to valproate (Depakine-Chrono) 3000 mg/day (n = 20) or placebo (n = 20). The p...

central nervous system axons fail to regenerate after spinal cord injury (sci), partially due to the accumulation of extracellular matrix molecules in the lesion and formation of the glial scar. depakine, as known as histone deacetylase inhibitor, has neuroprotective effects. this study evaluated the histological changes (cavitation and axon regeneration) after sci associated with (following ad...

Risperidone, as all atypical antipsychotics, can cause hyperprolactinemia which can in turn lead to galactorrhea. Mood stabilizers, one of which is valproic acid and its derivate "Depakine Chrono", are rarely linked with symptomatic hyperprolactinemia and do not alter prolactin concentrations. This case is based around a patient suffering from a bipolar disorder that has been psychiatrically tr...

Purpose: To evaluate the erosive effect of pediatric liquid medicinal syrups on primary and permanent enamel. Materials methods: Eighty teeth were equally divided into eight subgroups (n=10), according to immersion solutions: Depakine, Ventolin, Sansovit, Artificial saliva. The cycles drugs conducted under a 1-min agitation three times daily for 28 days. Enamel microhardness measurements taken ...

Background: Many intracranial lesions can induce psychotic symptoms. Arachonoid cyst is one of the suspicious etiologies. A possible link between arachnoid cyst and psychosis gives an interest to the pathogenesis of psychotic symptoms. Here, we present a case of schizophrenia with a large cerebellar arachnoid cyst. Case Presentation: Ms. Lu is a 31-year-old woman with schizophrenia for 7 years...

Background: Many intracranial lesions can induce psychotic symptoms. Arachonoid cyst is one of the suspicious etiologies. A possible link between arachnoid cyst and psychosis gives an interest to the pathogenesis of psychotic symptoms. Here, we present a case of schizophrenia with a large cerebellar arachnoid cyst. Case Presentation: Ms. Lu is a 31-year-old woman with schizophrenia for 7 years...

spinal cord injury (sci), a common result of car accidents, high-altitude falls and crashes, and other violent injuries is increasing yearly. histone deacetylases (hdac) inhibitors including depakine the main characteristics of the use of anti-inflammatory. the purpose of this investigation is to evaluate the effect of depakine intervention on the acute sci at the chronic phase using functional...

The aim of this research was to investigate the technique for preparation of coated valproic acid and sodium valproate sustained-release matrix tablets. Different diluents were tested and selected as the effective absorbent for oily valproic acid. Effect of the amount of absorbent and hydroxypropylmethylcellulose on drug release from valproic acid-sodium valproate matrix tablets prepared with w...