results results showed that dex 1 significantly increased, while dex 30 and groups treated with zinc 10 mg/kg and zinc 20 mg/kg decreased total immobility time as compared to that of saline group. also there was a significant decrease of total immobility time when zinc administered to rats already received dex 1, compared with that of control group. conclusions the current study findings sugges...

depression is a heterogenous, multifaceted disorder with symptoms manifested at the psychological, behavioral and physiological level. therefore, present study was designed as a model to analyze the long lasting effects of methylmercury chloride in male rats with a focus on depression like behavior. male albino rats of wistar strain were exposed orally to a dose of 2 mg/kg of methylmercury chlo...

Depression is a heterogenous, multifaceted disorder with symptoms manifested at the psychological, behavioral and physiological level. Therefore, present study was designed as a model to analyze the long lasting effects of methylmercury chloride in male rats with a focus on depression like behavior. Male albino rats of Wistar strain were exposed orally to a dose of 2 mg/kg of methylmercury chlo...

The aims of the present study were to investigate whether exercise can improve the depression-like behavior caused by estrogen deficiency. Given that decreased level of brain-derived neurotrophic factor (BDNF) in many brain areas including hippocampus and prefrontal cortex is associated with estrogen deficiency-induced depression-like behavior, we also determined whether exercise affects the le...

Background Cognitive dysfunction is among the key symptoms of major depressive disorder and can be affected by antidepressants. Cognitive decline also occurs in normal aging. The effects of different antidepressants on affective and cognitive domains in older subjects are seldom assessed simultaneously. Methods Healthy middle-aged female mice received vehicle or antidepressant (vortioxetine, ...