objective: the present study aimed to compare the effectiveness of metacognitive therapy (mct) and cognitive-behavior therapy (cbt) in treating iranian patients with major depressive disorder (mdd). methods: thirty three outpatients meeting dsm-iv-tr criteria for mdd without any other axis i and ii disorders were randomly assigned to one of three treatment conditions, i.e. mct, cbt and pharmaco...

Advanced societies face increased health problems related to various stresses. Chronic psychological stress is a major risk factor for psychiatric disorders such as depression. Although therapeutic agents reduce several symptoms of depression, most have side effects in a broad range of the population. Furthermore, some victims of depression do not show significant improvement with any drugs, so...

The effects of tamoxifen (TAM) on anxiety and depression-like behavior in ovariectomized (OVX) and naïve female rats were investigated. The animals were divided into Sham-TAM, OVX-TAM, Sham and OVX groups. Tamoxifen (1 mg/kg) was administered for 4 weeks. In the forced swimming test, the immobility times in the OVX and Sham-TAM groups were higher than in the Sham group. In the open field, the n...

BACKGROUND In addition to cognitive deficits, Alzheimer's disease (AD) is associated with other neuropsychiatric symptoms, including severe depression. Indeed, depression often precedes cognitive deficits in patients with AD. Unfortunately, the field has seen only minimal therapeutic advances, underscoring the critical need for new treatments. P7C3 aminopropyl carbazoles promote neuronal surviv...

OBJECTIVE Brain-derived neurotrophic factor (BDNF) and its specific receptor, tropomyosin-related kinase (TrkB), play important roles in treating depression. In this experiment, we examined whether 7,8-dihydroxyflavone, a novel potent TrkB agonist, could reverse the behavioral and biochemical abnormalities induced by the chronic mild stress (CMS) paradigm in rats. METHODS SD rats were exposed...

Major depression has various types of symptoms and disease courses with inconsistent response to monoamine-related antidepressants. Thus, monoamine theory may not be the only pathophysiologic pathway relevant to depression. Recently, it has been suggested that regulatory T cell (Treg) is associated with depression. Based on our previous study that showed decreased regulatory T cell (Treg) popul...

depression, anxiety and psychotic disorders, facilitating research on AUD and depression within the context of the broader field of substance-related comorbidity. Continued refinement of methods to collect and analyze real-time assessments of drinking, alcohol-related symptoms and depressed affect [13] will also be essential to advance knowledge. Interestingly, the induced-independent typology ...

Several severe stressful situations, e.g., natural disaster, infectious disease out break, and mass casualty, are known to cause anxiety, depression and cognitive impairment, and preventive intervention for these stress complications is worth exploring. We have previously reported that the serotonin-norepinephrine-dopamine reuptake inhibitor, venlafaxine, as well as voluntary wheel running are ...

Depression during pregnancy and the postpartum period is a growing health problem, which affects up to 20% of women. Currently, selective serotonin reuptake inhibitor (SSRIs) medications are commonly used for treatment of maternal depression. Unfortunately, there is very little research on the long-term effect of maternal depression and perinatal SSRI exposure on offspring development. Therefor...

The aim of this study was to compare the effect of selected drugs, Intellan and cyanocobalamin on some aspects of animal behavior, like effect on memory, depression, gross behavior and exploratory activity. Results of present investigations reveals cyanocobalamin to be a good memory enhancer and intellan also showed memory boosting effects in addition to anti-anxiety activity which affects over...