The pharmacokinetics of the broad-spectrum penicillin Bay k 4999 were studied in six healthy male volunteers. A 2-g dose was given by the intravenous route. The tissue penetration of the antibiotic was studied by both dermabrasion and blister techniques. A total of 26.4% of the drug was recovered in the urine in 24 h, 79% of this being excreted in the first 2 h. The elimination half-life in ser...

The combination of skin ablation and 5-Fluorouracil (5-FU) ointment was previously tried in the treatment of vitiligo, and good results were specifically reported in glabrous skin without follicular melanocyte reservoirs. Methods. This study was carried out on the skins of seven guinea pigs: three were treated with mechanical dermabrasion plus topical 5-FU in an achromic area contiguous to a pi...

IntroductIon traditional surgical treatments to improve facial wrinkles and skin laxity include face-lifting and blepharoplasty, alone or combined with chemical peels and dermabrasion.1 Chemical peels and dermabrasion are effective, but their use around the eyes and mouth is limited1 and the risks of scarring, pigmentation problems and unpredictability in the depth of tissue injury are consider...

Acne scars show a great variety in there clinica! appearance and therefore very often cannot be effectively corrected by a single treatment modality alone. Traditionally chemical peeling is continued with punch excision and also by dermabrasion. Laser skin resurfacing has been added to the numerous treatment options for acne scars. Whereas laser resurfacing showed good results in mild acne scar...

Objective: To study patients coming for surgical removal of their tattoos with regard to treatment outcome. Methodology: It is a descriptive and observational study, conducted at Plastic, Reconstructive & Micro-Surgery Department of Dow Medical College & Civil Hospital, Karachi over a period of one year. Twenty four patient, 18 males and 6 females, who came for tattoo removal and were found to ...

Background: Different modalities have been tried in order totreat stable vitiligo. Culturing melanocytes is time consumingand expensive. Therefore, new methods using autologousmelanocytes are sought. We aimed to compare the mixed nonculturedautologous melanocytes of the outer root sheath andthe bulge area of hair follicle transplantation plus dermabrasionwith dermabrasion alone in stable genera...

BACKGROUND Various surgical procedures for correcting stable vitiligo exist but these have their own limitations. Autologous, non-cultured, non-trypsinized, melanocyte plus keratinocyte grafting is a new and simple method of vitiligo surgery. OBJECTIVE The study aimed to evaluate efficacy of a new grafting technique in vitiligo patches. METHODS Eighteen vitiligo patches underwent this proce...