The human body is exposed to a wide array of xenobiotics in one’s lifetime, from food components to environmental toxins to pharmaceuticals, and has developed complex enzymatic mechanisms to detoxify these substances. These mechanisms exhibit significant individual variability, and are affected by environment, lifestyle, and genetic influences. The scientific literature suggests an association ...

BACKGROUND/AIM The need for sensitive biological markers to detect and prove recent drinking has been the focus of many research groups. The aim of our study was to investigate the alterations of biological markers in a population of alcohol dependent individuals during the detoxification period. PATIENTS AND METHODS Fifty-two alcohol-dependent individuals were admitted for alcohol detoxifica...

The paper examines trends in the use of inpatient substance abuse detoxification provided at general hospitals using data from the Healthcare Utilization and Cost Project - National Inpatient Survey. Most persons who received inpatient detoxification did not also receive rehabilitation while an inpatient. The percentage receiving rehabilitation declined between 1992 and 1997 from 38.9% to 21.1%...

Unintentional loss of herbicides into drainage ditches, shores or other waterbodies may cause large problems in farmland. Therefore strategies for the phytoremediation of agrochemicals and especially herbicides have become a topic of great interest in many agricultural areas. However, in order to establish effective biological pollution control, information on the detoxification capacity of rip...

Background: Loperamide is used as an antidiarrheal drug and is available over-the-counter. It cannot pass the blood-brain barrier and it does not have a considerable abuse potential. It can lead to dangerous cardiac arrhythmia.Case Report: Herein, we report a 35-year-old man with a 13-year history of abusing opioids who had undergone detoxification for four times during this period. He underwen...

Medication overuse headache (MOH) is preventable and treatable. However, MOH is a major contributor to headache-related disability, affecting up to 70% of patients in headache specialty practices (1). The management of MOH is complicated as patients often have difficulty stopping the overused medication and relapse rates following successful detoxification are high, consistent with the concept ...

Laboratory experiments have been performed to investigate photocatalytic detoxification by using TiO2 photocatalyst for treating dairy effluent. Various operational parameters such as catalyst concentration, initial concentration, angle of tilt of solar flat plate reactor and flow rate were investigated. Results indicated that the photocatalytic detoxification process can efficiently treat dair...

Since its inception in 1968, the San Francisco Drug Treatment Program, Inc., has responded to the mental and physical health needs of narcotic addicts. The search for safer, cost-effective detoxification alternatives grew from the controversial use of methadone and propoxyphene napsylate (Darvon N R) and has led to an exploration of nontraditional methods of detoxification which would address t...

This paper examines the determinants of whether an individual received continuing treatment/rehabilitation services 30 days after receiving inpatient substance abuse detoxification. Data came from 1997-1999 employer health insurance claims. Only 49.4% of detoxification episodes were followed by continuing mental health or substance abuse treatment within 30 days after discharge. Some of the fac...

The detoxification of the phytoalexin brassinin to indole-3-carboxaldehyde and S-methyl dithiocarbamate is catalyzed by brassinin oxidase (BOLm), an inducible fungal enzyme produced by the plant pathogen Leptosphaeria maculans. Twenty-six substituted quinolines and isoquinolines are synthesized and evaluated for antifungal activity against L. maculans and inhibition of BOLm. Eleven compounds th...