Central MessageInvestigators of noninferiority trials need thorough understanding statistical and technical peculiarities for their results to have valuable clinical influence.See Article page 2119. Investigators influence. See There are 3 main types based on the hypothesis tested. Superiority compare 2 treatments determine which is better, equivalence test whether a new treatment as effective ...

C JHP – Vol. 63, No. 1 – January–February 2010 JCPH – Vol. 63, n 1 – janvier–février 2010 Statement (the last 2 documents in collaboration with the Pharmacist Prescribing Task Force). A most prolific year! After several years of hard work, the Association des pharmaciens des établissements de santé du Québec and CSHP were glowing with excitement when they launched the fourth edition of Care Bey...

The publication of Fisher's correspondence on statistics has shed new light on his views on randomization. Quotations from this correspondence and from other works of Fisher are used to illustrate the role of randomization in clinical trials. It is concluded that Fisher's views not only are coherent but, despite having been developed over 60 years ago and with particular reference to agricultur...