Objective(s): The present study was aimed to evaluate the time-mannered and dose-dependent effects of 5α-dihydrotestosterone (5α-DHT) on the proliferation and differentiation of bone forming cells using MC3T3-E1 cells. Materials and Methods: Cell proliferation was analyzed using MTS and phase contrast microscopic assays. Osteogenic differentiation was assessed through a series of in vitro exper...

We recently reported that castration exacerbates albuminuria, glomerulosclerosis, and tubulointerstitial fibrosis associated with diabetic renal disease. The aim of the present study was to examine whether these effects of castration can be attenuated with dihydrotestosterone (DHT) supplementation. The study was performed in castrated male Sprague-Dawley, streptozotocin-induced diabetic rats tr...

Abstract Introduction Although Hypoactive Sexual Desire Disorder (HSDD) is a common condition with relevant impact on women’s quality of life, approved androgenic formulations for its treatment are lacking. In previous studies, we demonstrated that the administration Dihydrotestosterone (DHT), non-aromatizable androgen, in ovariectomized (OVX) Long-Evans rats primed Estradiol Benzoate (EB), enh...

Static DHT topologies influence important features of such DHTs such as scalability, communication load balancing, routing efficiency and fault tolerance. Nevertheless, it is commonly recognized that the primary difficulty in designing DHT is not in static DHT topologies, but in the dynamic DHT algorithm which adapts various static DHT topologies to a dynamic network at Internet. As a direct co...

     CA1 region of hippocampus has an important role in learning and memory. Previous reports have shown that androgens like testosterone and its metabolites are present in high concentration in CA1 region of hippocampus. Androgen receptors have also high density in this region. Therefore, it is suggested that neurohormones in CA1 have an important role in learning and memory. It is likely that...

Distributed Hash Tables (DHTs) provide scalable mechanisms for implementing resource discovery services in structured Peer-to-Peer (P2P) networks. However, DHT-based lookups do not support some types of queries which are fundamental in several classes of applications. A way to support arbitrary queries in structured P2P networks is implementing unstructured search techniques on top of DHT-based...

Dihydrotestosterone (DHT) has been shown to promote breast cancer growth via different mechanisms. In addition to binding to ERα, the DHT membrane receptor exists on integrin αvβ3. Resveratrol induces p53-dependent apoptosis via plasma membrane integrin αvβ3. Resveratrol and DHT signals are both transduced by activated ERK1/2; however, DHT promotes cell proliferation in cancer cells, whereas re...

We propose an evaluation method of large-scale distributed hash tables by network emulator that allows us to evaluate not only DHT algorithms but also DHT implementations. Evaluating DHT implementations is important for DHT application developers since it influences how an application utilizes a DHT. We built a platform to support our method and evaluated four implementations with various scena...

An effective encapsulation solution for flexible CIGS is urgently needed to ensure a competitive market entry of the technology. In this work, we demonstrate feasibility effectively encapsulate module-level (10 × 10 cm2) CIGS/glass solar cells by employing thin Al2O3 barrier layer grown atomic deposition (ALD). As determined direct methodology, nm ALD-Al2O3 proved be sufficient in preventing el...