Rep. Ser. No. 86; DHEW Pub!. No. (NIH) 78-1336), Bethesda, MD, US Department of Health, Education, and Welfare 6Yan Duuren, B.L., Seidman, 1., Melchionne, S. & Kline, S. A. (1985) Carcinogenicity bioassays of bromoacetaldehyde and bromoethanol potential metabolites of dibromoethane. Teratog. Carcinog. Mutagenesis, 5,393-403 7National Toxicology Program (1982) Carcinogenesis Bioassay of 1,2-Dibr...

The ability of a series of haloalkanes, haloethanols and haloacetaldehydes to induce mutations in Salmonella typhrimurium and preferentially to inhibit the growth of DNA polymerase-deficient E. coli (pol A(+)/pol A(-)) was investigated. For the haloalkanes investigated, the order of reactivities towards the E. coli pol A(+)/pol A(-), was: 1,1,2,2-tetrabromoethane > 1,1-dibromoethane > 1,1,2,2-t...

Two of the most representative halogenated aliphatic hydrocarbons, 1,2-dibromoethane and 1,1,2,2-tetrachloroethane, were tested in the two-stage cell transformation model for analysing the promoting ability. Both of these compounds had previously been found to exert genotoxic effects, probably acting as moderate initiators. BALB/c 3T3 cells were initiated with subtransforming doses of N-methyl-...

Alkylation of 2-mercaptopyridine with 1,2-dibromoethane affords a cyclic dihydrothiazolopyridinium salt that can serve as a precursor of 2-aminopyridines. Its reaction with primary or secondary amines, either neat or in DMSO, under mild conditions gives the title compounds.

A mathematical model describing the behavior of a continuous culture that degrades 1,2-dichloroethane and receives a shock loading of another compound was developed. The model takes into account possible cell death due to toxicity, growth inhibition and additional growth of cells on the second carbon source. Biodegradation is coupled to cell growth on the additional carbon source or by incomple...

A four-component reaction of aryldiazonium tetrafluoroborates, sulfur dioxide, 1,2-dibromoethane, and hydrazines under metal-free conditions is described, providing a novel and efficient approach to 2-arylsulfonyl hydrazones. This transformation proceeds smoothly via insertion of sulfur dioxide under mild conditions with good functional group tolerance.

Conversion of halogenated aliphatics by haloalkane dehalogenase proceeds via the formation of a covalent alkyl-enzyme intermediate which is subsequently hydrolyzed by water. In the wild type enzyme, the slowest step for both 1,2-dichloroethane and 1,2-dibromoethane conversion is a unimolecular enzyme isomerization preceding rapid halide dissociation. Phenylalanine 172 is located in a helix-loop...