Dieldrin accumulation and elimination in muscle tissue of channel catfish (Ictalurus punctatus) from water and food was determined in the laboratory. Twenty-eight-day exposure of fish 150-225 mm and 350-400 mm long to 75 parts per trillion (ng/liter) dieldrin resulted in the larger catfish consistently accumulating more dieldrin than the smaller fish. After 28 days of elimination, dieldrin leve...

Pesticide exposure has been implicated in the etiopathogenesis of Parkinson's disease (PD); in particular, the organochlorine insecticide dieldrin is believed to be associated with PD. Emerging evidence indicates that histone modifications play a critical role in cell death. In this study, we examined the effects of dieldrin treatment on histone acetylation and its role in dieldrin-induced apop...

Twenty-eight crossbred 2-year-old ewes were used · to determine the effects of pregnancy and lacta­ tion on the body storage of DDT and dieldrin and on their elimination in milk. Pregnancy did not significantly affect total DDT degradation in ewes, but significantly affected dieldrin metaoo­ lism. Body fat from pregnant animals averaged higher in dieldrin concentration at parturition than did t...

Exposure to organochlorinated pesticides such as dieldrin has been linked to Parkinson's and Alzheimer's diseases, endocrine disruption, and cancer, but the cellular and molecular mechanisms of toxicity behind these effects remain largely unknown. Here we demonstrate, using a functional genomics approach in the model eukaryote Saccharomyces cerevisiae, that dieldrin alters leucine availability....

Aldrin (C12H8Cl6) and dieldrin (C12H8Cl6O) are two organochlorine insecticides that were used for agricultural and public health purposes from the early 1950s until 1989, when their manufacture in the United States was discontinued. Aldrin and dieldrin were popular pesticides for corn and cotton crops, and were used as a prophylactic and for treatment of timber against termite infestation. Cons...

Breast cancer is the most common cancer in Western women and while its precise etiology is unknown, environmental factors are thought to play a role. The organochlorine pesticide dieldrin is a persistent environmental toxicant thought to increase the risk of breast cancer and reduce survival in the human population. The objective of this study was to define the effect of developmental exposure ...

Three commercial peanut varieties (Starr Spanish, Florunner, and Florigiant) were grown in field plots treated with 0, 1, and 4 kg dieldrin per hectare. Soil samples were taken at planting; soil and aerial portions were sampled 10 weeks into the growing season. Peanuts were grown to maturity (16 weeks), harvested, and dried before shelling. Soils, hay, shells, and meats were analyzed for dieldr...

The main constituent of the insecticide dieldrin has been studied in male and female rats. The LD50s depend on the route of injection and, after intravenous infusion, on the rate of infusion. After oral injection of a 4% solution in arachis oil, deaths take place within six hours or from two to seven days later; but the first convulsion occurs at 40 min. over a wide range of doses. For further ...

Mallard ducks were fed diets containing various levels of technical DDT or chemically pure p,p'-DDT, or dieldrin. Either technical DDT or p,p'-DDT at 20 ppm or greater, or dieldrin at I 0 ppm caused a statistically significant reduction in e9gshell thickness, weight, and calcium. Shells of eggs from ducks fed 40 ppm of p,p -DDT were about 20% thinner than those from control ducks, and shells of...