background: zinc (zn) as an important trace element is essential for testicular development and spermatogenesis. molecular mechanism of zn action in the reproductive system may be related to metal binding low-molecular weight proteins, metallothioneins (mt). our objective was to determine the effect of zn on two important isoforms of mt, mt1m and mt1g genes expression on testicular sertoli cell...

objective(s):  apoptosis is a tightly regulated process and plays a crucial role in autoimmune diseases. because abnormalities in apoptosis are considered to be involved in the pathogenesis of systemic lupus erythematosus (sle), in present study we studied the apoptosis in t lymphocytes from iranian sle patientsat protein and gene expression levels for some molecules which are involved in apopt...

extracellular ca 2+ concentration ([ca2+]o) may be one of the factors affecting atrial natriuretic factor (anf) release. in the previous studies, there are opposite reports about the effect of [ca2+]o on anf secretion. therefore, the effect of [ca2+]o depletion on anf secretion and gene expression was studied in the present research. isolated right atria from rats were perfused for 6 and 2 hour...

Background and Objective: Burn wound infections caused by Pseudomonas aeruginosa exhibiting β-lactam antibiotic resistance are one of the greatest challenges of antimicrobial treatment. In this context, P. aeruginosa strains harboring resistance mechanisms, such as production of extended-spectrum beta-lactamases have the highest clinical impact no the management of burn wound infections. The ai...

Background Cytochrome aromatase p450, encoded by the gene CYP19A1, is a key enzyme for estrogen biosynthesis. Among the multiple promoters of CYP19A1, the proximal promoter PII is the most active ones in ovary and endometrium. Endometriosis is a chronic estrogen dependent gynecological condition characterized by the presence of ectopic glands and stroma outside the uterine cavity. Recently, evi...