نتایج جستجو برای: dimethyl itaconate endometritis lps nf
تعداد نتایج: 96153 فیلتر نتایج به سال:
Objective(s): Endometritis is the inflammation of the uterine lining that is associated with infertility. It affects milk production and reproductive performance and leads to huge economic losses in dairy cows. Dimethyl itaconate (DI), a promising chemical agent, has recently been proved to have multiple health-promoting effects. However, the effects of DI on endometri...
Itaconate is an immunoregulatory metabolite produced by myeloid cells and plays a key role in the regulation of immune response. Itaconate, on one hand, able to suppress activity succinate dehydrogenase (SDH), thereby making significant contribution metabolic reprogramming cell. On other itaconate can regulate number transcription factors regulators, affecting gene expression. In most experimen...
The purpose of this study was to investigate the effects of thymol on lipopolysaccharide (LPS)-induced inflammatory responses and to clarify the potential mechanism of these effects. LPS-induced mouse endometritis was used to confirm the anti-inflammatory action of thymol in vivo. RAW264.7 cells were used to examine the molecular mechanism and targets of thymol in vitro. In vivo, thymol markedl...
Abstract Itaconate is a unique regulatory metabolite that induced upon toll-like receptor (TLR) stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death phenotypes associated with itaconate production activated macrophages. We show endogenous key regulator of the signal 2 NLRP3 inflammasome activation after long LPS priming which establishes to late activat...
Dimethyl sulfoxide (DMSO), an amphipathic molecule composed of one highly polar sulfinyl group and two nonpolar methyl groups, is considered excellent solvent due to its capability dissolve many compounds. Therefore, DMSO widely used solubilize drugs for therapeutic applications. reported possess anti-inflammatory, anticancer, antioxidative capacities, the anti-inflammatory efficacy has been in...
Objective(s): Aberrant expression of CCL5 has been found in several kinds of inflammatory diseases, and the roles of CCL5 in these diseases have also been reported. However, the role of CCL5 in infantile pneumonia is still unclear. Thus, the function and acting mechanism of CCL5 in the in vitro model of infantile pneumonia were researched in this study. Materials and Methods: Human fetal lung f...
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