نتایج جستجو برای: diosgenin diabetes mellitus streptozotocin heart oxidative stress antioxidant

تعداد نتایج: 1169948  

Journal: :journal of basic and clinical pathophysiology 0
jafar golshahi department of cardiology, school of medicine, isfahan university of medical sciences, isfahan, iran. farshad roghani-dehkordi department of cardiology, school of medicine, isfahan university of medical sciences, isfahan, iran.

background and objective: chronic diabetes mellitus (dm) leads to cardiovascular dysfunction. diosgenin is a natural steroidal saponin with cardiovascular protective potential. in this research study, the beneficial effect of diosgenin was evaluated on some markers of oxidative stress in cardia tissue of streptozotocin (stz)-diabetic rats. materials and methods: male wistar rats (n = 28) were d...

Farshad Roghani-Dehkordi* Jafar Golshahi,

Background and Objective: Chronic diabetes mellitus (DM) leads to cardiovascular dysfunction. Diosgenin is a natural steroidal saponin with cardiovascular protective potential. In this research study, the beneficial effect of diosgenin was evaluated on some markers of oxidative stress in cardia tissue of streptozotocin (STZ)-diabetic rats. Materials and Methods: Male Wistar rats (n = 28) were ...

Journal: :journal of basic and clinical pathophysiology 2013
ali . samadi abbasali gaeini aliasghar ravasi mehdi hedayati mostafa rahimi

abstract background and objective: it has been shown that oxidative stress increases in diabetes and it has an important role in its development and subsequent complications. thus, the aim of this study was to investigate the effect of acute resistance exercise on oxidative stress in skeletal muscle and cardiac tissues of streptozotocin-induced diabetic rats. materials and methods: twenty male ...

حجتی, ویدا, نوروزی, پیراسته, پاک دشت, زهرا, کلالیان مقدم, حمید,

Background and Objective: Diabetes as one of the most prevalent and chronic diseases is dramatically increasing worldwide and Iran is no exception. Diabetes mellitus with oxidative stress and overproduction of reactive oxygen species (ROS) can cause metabolic disorders and deactivate the antioxidant defense. Palmatine hydrochloride has anti-diabetic and antioxidant effects among its various pha...

2016
Jafar Golshahi Farshad Roghani-Dehkordi

Materials and Methods: Male Wistar rats (n = 28) were divided into equalsized control, diosgenin-treated control, diabetic, and diosgenin-treated diabetic groups. Diabetes was induced by a single intraperitoneal injection of streptozotocin (60 mg/kg). Diosgenin was administered p.o. at a dose of 40 mg/kg for 7 weeks. Some markers of oxidative stress including malondialdehyde (MDA), superoxide d...

Journal: :journal of cell and molecular research 0
samaneh jamshidi mehrdad lahouti mohammad taher boroushaki ali ganjeali ahmad ghorbani mehdi bihamta toosi

diosgenin is an important compound in pharmaceutical industry. it has various effects such as hypocholesterolemic action or antioxidant activity in hiv infected patients. biological oxidation pathways are involved in causing or aggravating heart disease. this study investigated the potential protective effect of diosgenin on cell viability and antioxidant defenses of cultured h9c2 cells submitt...

ژورنال: دانشور پزشکی 2012
افشار, رضا , روغنی, مهرداد , پوراسد مهربانی, فاطمه ,

 Background and Objective: Diabetes mellitus accompanies enhanced oxidative stress and decreased activity of antioxidant defense system. Due to the significant role of enhanced oxidative stress in development of renal damage and nephropathy in diabetes and with regard to antidiabetic and antioxidant effect of apigenin, this study was conducted to evaluate the effect of this flavonoid on ...

Journal: :iranian journal of pharmaceutical research 0
mohammad sharifzadeh dept. of pharmacology and toxicology, faculty of pharmacy, tehran university of medical sciences, tehran, iran akram ranjbar ) department of toxicology and pharmacology, school of pharmacy, hamadan university of medical sciences, hamadan, iran asie hossini dept. of pharmacology and toxicology, faculty of pharmacy, tehran university of medical sciences, tehran, iran. mahnaz khanavi departement pharmacogenosy.faculty of pharmacy,tehran university of medical sciences.tehran.iran

diabetes mellitus is associated with distribution of cognitive functioning. hyperglycemia diabetes mellitus is associated with distribution of cognitive functioning. hyperglycemia induced oxidative stress has been proposed as a cause of memory complications of diabetes including cognitive impairment. the aim of this study was to examine total green tea extract (tgte), a potent free radical scav...

2016
J. Revathy Sheik Abdullah

Diabetes mellitus is the most common serious metabolic disorder and it is considered to be one of the five leading causes of death in the world. Hyperglycemia-mediated oxidative stress plays a crucial role in diabetic complications. Hence, this study was undertaken to evaluate the protective effect of hesperetin on the plasma glucose levels and on the antioxidant defense system in streptozotoci...

2017
Mohammad Sharifzadeh Akram Ranjbar Asieh Hosseini Mahnaze Khanavi

Diabetes mellitus is associated with distribution of cognitive functioning. Hyperglycemia induced oxidative stress has been proposed as a cause of memory complications of diabetes including cognitive impairment. The aim of this study was to examine total green tea extract (TGTE), a potent free radical scavenger against spatial impairment in Streptozotocin-diabetic rats. Eight weeks after diabet...

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