background: the amount of literature concerning the implication of the red cell distribution width (rdw) in the assessment of ulcerative colitis (uc) activity is rather limited. the aim of this study is to investigate the potential role of rdw in the evaluation of uc disease activity. materials and methods: a total of 96 patients with uc and 51 age and sex-matched healthy volunteers were includ...

background: systemic lupus erythematosus is a systemic autoimmune disorder with unclear etiology. the importance of some genes in the development of systemic lupus erythematosus has been implicated. the gene polymorphism in codon 72 has attracted a lot of attention and its role in the occurrence or progression of many cancers and autoimmune diseases especially systemic lupus erythematosus has b...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: to determine the prevalence of cryoglobulins in iranian patients with systemic lupus erythematosus (sle) and evaluate the correlation of cryoglobulins with disease activity in these patients. materials and methods: in a cross-sectional study, we investigated 80 consecutive women who fulfilled the 1982 revised c...

at present, some clinical presentations and serological parameters such as products of complement activation and elevation of autoantibodies (e.g. dsdna antibodies), erythrocyte sedimentation rate (esr), levels of c-reactive protein (crp), or cytokines such as il-2/il-2 receptor, il-6 and il-10 are used as indirect serological markers with variable degrees of significance. to date, no specific ...

purpose: due to unhealthy lifestyles, there has been an increase in the prevalence of coronary artery disease (cad) and a reduction in its age of onset. given the high cost of diagnosis and treatment of cad, there is an urgent need to teach people strategies helpful in changing their lifestyles as this can help reduce the risk factors of the disease. therefore, the goal of the present study was...

background: nonalcoholic fatty liver disease (nafld) is the most common cause of chronic liver disease in the world. although some studies have been conducted about dietary intakes of these patients, but the results are inconsistent. the aim of this study was to survey all macronutrients and micronutrients included in dietary intake of these patients for better understanding the factors influen...

background: although physical activity (pa) has long been associated with cardiovascular disease (cvd), assessment of pa status has never been used as a part of cvd risk prediction tools. the aim of the present work was to examine whether the inclusion of pa status in a cvd risk model improves its predictive accuracy. methods: data from the 10‑year follow‑up (2002–2012) of the n = 2020 particip...

background: sandhoff disease is an autosomal recessive disorder caused by β-hexosaminidase deficiency and accumulation of gm2 ganglioside resulting in progressive motor neuron manifestations and death from respiratory failure and infections in infantiles. pathogenic mutations in hexb gene were observed which leads to enzyme activity reduction and interruption of normal metabolic cycle of gm2 ga...

parkinson's disease is a degenerative disorder of the central nervous system. the motor symptoms of parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain the cause of this cell death is unknown. homocysteine (hcy) is a non-protein amino acid. it is a homologue of the amino acid cysteine. the elevated levels of homocysteine in pl...

rheumatoid arthritis (ra) is a chronic autoimmune disease, which can lead to joint destruction and disability. pannus formation due to chronic synovitis is the hallmark of ra. oxidative stress as a consequence of immune cell activation and disease-modifying anti-rheumatic drugs can prevent inflammation and tissue destruction. silymarin, an antioxidant extract from silybum marianum, has been tra...