Corona virus disease 2019 (COVID-19) was declared as pandemic by WHO on March 10, 2020. Several countries around the globe have seen a two-wave pattern of reported cases. India is witnessing unprecedented spike in COVID-19 cases again since 2021 especially Maharashtra. Newer insights pathogenesis diseases, diagnosis and treatment modalities continue to evolve case novel infection. To study comp...

Parkinson’s disease (PD) is a neurodegenerative disorder that does not develop spontaneously in some animal species. PD can be induced experimentally in some laboratory animals including mouse, rat and horse. Globus pallidus (GP) and substantia nigra pars compacta (SNc) are damaged in patients with PD. The hallmark of PD is a progressive impaired control of movement, an alteration of autonomic ...

dacarbazine is an antitumor prodrug which is used for the treatment of malignant metastatic melanoma and hodgkin’s disease. it requires initial activation in liver through an n-demethylationreaction. the active metabolite prevents the progress of disease via alkylation of guanine bases in dna strands. in order to investigate the importance of imidazole ring and its dynamictautomerization in ant...

The genetic basis of hyperactivity of the sympathetic nervous system (SNA) in spontaneously hypertensive rats (SHR) was assessed by measuring SNA in animals derived from a backcross (BC) breeding program designed to isolate single gene differences causing changes in blood pressure. Selective breeding of the male hypertensive rats with inbred normotensive female Wistar/Lewis rats yielded progeny...

Purpose: To determine the effect of bacoside-A on Parkinson's disease (PD) in a rat model, and elucidate its mechanism action.Methods: A model PD was established by administration 5 µL 6-hydroxydopamine ascorbic acid (0.1 %). Measurement serum levels inflammatory factors carried out using enzyme-linked immunosorbent assay (ELISA) kits. Western blotting used to Bax, cytochrome c Bcl-2 hippocampu...

Human leptospirosis, or commonly known as the “rat urine disease” is a zoonotic disease caused by bacterium called Leptospira sp. acquired via of animal carriers. It believed that incidence rate leptospirosis has been under-reported due to its unspecific clinical Symptoms and limitations current diagnostic methods. Leptospirosis can be effectively treated with antibiotics in early stage, it cur...

Abstract Background and Aims Polycystic kidney disease (PKD) is a congenital fibrocystic disorder where cysts are primarily forming within the kidneys causing enlargement, loss of function resulting in chronic for which there no curative treatment. Consequently, PKD classified as medical condition with high unmet therapeutic need. Animal models improved clinical translatability can optimally in...