پورخداداد, سهیلا
مرکز تحقیقات داروهای گیاهی رازی، دانشگاه علوم پزشکی لرستان
[ 1 ] - اثر اولئوروپئین بر حافظۀ احترازی غیرفعال در مدل آلزایمر القاشده توسط کلشیسین در موش بزرگ آزمایشگاهی
Background and Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disease along with learning and memory disorders. Oleuropein is a phenolic compound with antioxidant and neuroprotective properties that reduces oxidative stress and improves cognitive function. The purpose of this study was to investigate the effect of oleuropein pretreatment on the colchicine- induced cognit...
[ 2 ] - Interaction of colchicine with nitric oxide in CA1 on the expression of drug seeking behavior induced by morphine
Introduction: According to previous studies, colchicine causes neuronal destruction and learning depression. In this project, effects of colchicine injection into the CA1 and interaction between colchicine and nitric oxide (NO) in this area on the expression of drug-seeking behavior were investigated. Methods: Wistar rats (250-300 g) were bilaterally cannulated at the CA1 area. Colchicine (2...
[ 3 ] - Minocycline Enhance Restorative Ability of Olfactory Ensheathing Cells by Upregulation of BDNF and GDNF Expression After Spinal Cord Injury
Purpose: Spinal cord injury is a global public health issue that results in extensive neuronal degeneration, axonal and myelin loss and severe functional deficits. Neurotrophic factors are potential treatment for reducing secondary damage, promoting axon growth, and are responsible for inducing myelination after injury. Olfactory ensheathing cells (OECs) and minocycline have been shown to promo...
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