neurite outgrowth from dorsal root ganglion (drg) explants is a method of evaluating neurotrophic activity of growth factors. when complete medium containing collagen was supplemented with nerve growth factor (ngf) drg outgrowth was observed after 18 h. in the absence of ngf and in the presence of collagen, the drg outgrowth took place after 72 h. in wells not supplemented with collagen gel in ...

BACKGROUND When applying pulsed radiofrequency on dorsal root ganglia for treating chronic lower back pain, maximum efficiency can be expected when a needle is placed 1-2 cm peripheral to the dorsal root ganglion. The object of this study is to analyze images taken after adding contrast to transforaminal epidural injection, categorize root ganglia according to anatomical position, and provide a...

RNA from rat dorsal root ganglia was analyzed in search of potentially beneficial cytokines that are induced in dorsal root ganglia by nerve injury. By reverse transcription, the PCR, and Southern blotting, interleukin-6 mRNA was detected during development but not in normal adult dorsal root ganglia, reappeared within 1 d of sciatic nerve transection, was maximally increased after 2 and 4 d, a...

Neurogenesis continues in various regions of the central nervous system (CNS) throughout life. As the mitogen basic fibroblast growth factor (bFGF) can proliferate neuronal precursors of CNS neurons in culture, and is also upregulated within adult dorsal root ganglia following axotomy, it is possible that the postnatal dorsal root ganglia contain bFGF-responsive neuronal precursors. We undertoo...

Sympathetic nerve terminals on blood vessels within the dorsal root ganglia sprout after sciatic nerve lesions in the rat. The mechanism underlying this phenomenon is not clear, but might be predicted to involve nerve growth factor or its homologs because these factors are known to trigger collateral sprouting of undamaged sympathetic noradrenergic terminals. We have found that sciatic nerve le...

two patients with phantom pain were selected for the study. after a positive response to segmental nerve blockade at the l4 and l5 nerve roots, prf was performed on the l4 and l5 dorsal root ganglia. global clinical improvement was good in one patient, with a 40% decrease in pain on the visual analogue scale (vas) in 6 months, and moderate in the second patient, with a 30% decrease in pain scor...

Chemical calcium indicators have been commonly used to monitor calcium (Ca2+) activity in cell bodies, i.e., somata, of isolated dorsal root ganglion neurons. Recent studies have shown that dorsal root ganglion somata play an essential role in soma-glia interactions and actively participate in the transmission of nociceptive signals. It is therefore desirable to develop methods to study Ca2+ ac...