objective(s) doxorubicin (dox), a widely used chemotherapeutic agent can give rise to serve cardiotoxicity by inducing apoptosis. curcumin, the active compound of the rhizome of curcuma longa l. has anti-inflammatory, antioxidant and anti-proliferative activities. curcumin has been identified to increase cytotoxicity in several cancer cell lines in combination with dox, but there is no study ab...

Thesis Abstract Background: Graphene oxide (GO) is a multifunctional carbon nanomaterial with tremendous potential in medical science including cancer therapy. It has unique physical, and chemical properties to be used as drug carrier such Doxorubicin (DOX). Aim: This study aimed load DOX on supramagnetic iron GO (GO/Fe3O4) passive active forms or without folic acid (FA) compare the anti-tumor ...

doxorubicin (dox) is an anthracycline antibiotic that has been used for a long time in therapy of an array of human malignancies either alone or in combination with other cytotoxic agents. the dose-dependent cardiotoxicity of dox significantly limits its anticancer efficacies. oxidative stress caused by enhanced production of reactive oxygen species is an important contributor to dox mitochondr...

doxorubicin (dox) induces oxidative stress leading to cardiovascular abnormalities. green tea extract (gte) is reported to possess antioxidant activity mainly by means of its polyphenolic constituent, catechins. our study was aimed to find out the effect of gte (100 mg/kg / day p.o. for 28 days) on dox induced (3 mg/kg, ip on days 1, 7, 14, 21, 28) cardiovascular abnormalities in rat heart. dox...

recently, specific attention has been paid to aptamers, short dna or rna, as a tool for cancer diagnosis and therapy. in the present study mcs nanogels were prepared by myristate: chitosan at 1:9 ratio and were characterized by several techniques. a selected ssdna aptamer(apt) capable of detecting lncap cells was linked to myristilated chitosan nanogels (apt-mcs) by glutaraldehyde and loaded wi...

In order to overcome drug resistant and enhance antitumor activity of DOX, a new pH-sensitive micelle (DOX/DQA-DOX@DSPE-hyd-PEG-AA) was prepared to simultaneously deliver DOX to nucleus and mitochondria. Drug released from DOX/DQA-DOX@DSPE-hyd-PEG-AA showed a pH-dependent manner. DOX/DQA-DOX@DSPE-hyd-PEG-AA induced the depolarization of mitochondria and apoptosis in MDA-MB-231/ADR cells and A54...

Doxorubicin (DOX) is one of the drugs necessary for treatment 10 most common types cancer. The leading adverse effect limiting clinical use DOX cardiotoxicity. Given that literature data indicate a protective role carotenoids in doxorubicin-induced toxicity, our study we compared cardioprotective mixture pumpkin and commercially available antioxidant preparation. Animals were distributed 8 grou...

Introduction: Nephropathy is defined as rational loss of renal function related with glomerulosclerosis and declining glomerular filtration rate. Inflammation and oxidative stress play a critical role in nephropathy. Plantago major has antioxidant effects. The aim of present study is the investigation of the effect of Plantago major hydro-alcoholic extract on the oxidative stress and renal func...