نتایج جستجو برای: drug regulation
تعداد نتایج: 1107546 فیلتر نتایج به سال:
Purpose: This study compared the effectiveness of group cognitive-behavioral therapy based on coping skills (CBT) and methadone maintenance therapy (MMT) in improvement of emotional regulation strategies and prevention of relapse. Method: The method of the present study was semi-experimental research design (pre-test-post-test with witness group). For sampling 45 substance abuse people who had ...
Background: Clients visiting methadone maintenance treatment (MMT) clinics frequently relapse during the course of treatment. The present study aimed to investigate the relationship between family communication patterns and resiliency and craving for drugs through the mediatory role of difficulty in cognitive emotion regulation among clients being treated by methadone. Methods: It was a descri...
Aim: Today, third wave therapies in psychotherapy shift their attention from challenging cognitions to awareness and acceptance of feelings, emotions, cognitions and behaviors. Therefore, this research aimed to compare of efficacy of group psychotherapy based on acceptance and commitment therapy, with mindfulness on craving and cognitive emotion regulation in methamphetamine addicts. Method: Re...
Identification of transcription factors for drug-associated gene modules and biomedical implications
MOTIVATION One of the major findings in systems biomedicine is that both pathogenesis of diseases and drug mode of action have a module basis. However, the transcription factors (TFs) regulating the modules remain largely unknown. RESULTS In this study, by using biclustering approach FABIA (factor analysis for bicluster acquisition), we generate 49 modules for gene expression profiles on 1309...
Objective Schizophrenia is the most debilitating psychiatric disorder with the highest psychiatric ward admission rate. Drug therapy is the first line of treatment. However, it does not result in appropriate therapeutic responses in many patients, and they experience emotional regulation difficulties and psychosis symptoms after initial symptom resolution. Cognitive-behavioral therapy (CBT) is ...
MicroRNAs (miRNAs) involved in regulation of the genes. The CCAAT/enhancer-binding protein-α (CEBPα) is a crucial transcription factor for normal hematopoiesis and cell cycle that frequently disrupted in human acute myeloid leukemia (AML). The miR-182 up-regulation in several malignant diseases such as AML was reported, in the other hand bioinformatics analysis revealed CEBPα targeted by miR-18...
Objective: The aim of this study was to compare dysfunctional attitudes, cognitive distortions, and difficulty in emotion regulation between people with substance abuse and normal people. Method: The research method of this study was descriptive and causal-comparative. The population of this study consisted of the men with substance abuse (opium and opium sap) who had referred to one of the reh...
Drug polymorphs are defined as a different arrangement of the same active compounds in crystalline form, which can potentially affect its therapeutic activity by changing the dissolution profile of drug upon administration. Discovery of new polymorphs therefore can provide added value for a previously marketed drug, due to the new advantages provided by the novel polymorph. Therefore, there is ...
Issues of drug regulation and safety are a familiar concern within the pharmaceutical industry and often do not emerge until several years after a drug has been on the market. The antifibrinolytic drug aprotinin (Trasylol) was developed by Bayer Pharmaceuticals and approved to prevent excessive bleeding in patients undergoing coronary artery bypass grafting surgery. After several years of wides...
Differences in expression of drug response-related genes contribute to inter-individual variation in drugs' biological effects. MicroRNAs (miRNAs) are small noncoding RNAs emerging as new players in epigenetic regulation of gene expression at post-transcriptional level. MiRNAs regulate the expression of genes involved in drug metabolism, drug transportation, drug targets and downstream signal m...
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