In this study, the effect of some processing parameters on bulk density, particle density, particle size and some of powder reconstruction properties such as dispersibility, Wettability and water solubility index of spray dried barberry (Berberis vulgaris) juice powders were investigated. A Pilot Spray Dryer (Two- Flow nozzle, counter- current, one cyclone) was employed for the spray d...

In this study, the effect of some processing parameters on bulk density, particle density, particle size and some of powder reconstruction properties such as dispersibility, wetability and water solubility index of spray dried barberry (Berberis vulgaris)  juice powders were investigated. A Pilot Spray Dryer (Two- Flow nozzle, counter- current, one cyclone) was employed for the spray drying pro...

Carvedilol (CAR) is a potent antihypertensive drug but has poor oral bioavailability (24%). A nanosuspension suitable for pulmonary delivery to enhance bioavailability and bypass first-pass metabolism of CAR could be advantageous. Accordingly, the aim of this work was to prepare CAR nanosuspensions and to use artificial neural networks associated with genetic algorithm to model and optimize the...

In order to achieve a homogeneous starting material for the production of dense Si3N4 by post-sintering of RBSN, the morphological and chemical characteristics of the Si-starting powders as well as the pore structure of the Si-powder compacts have to be optimized. In this context, the influence of the grain size distribution on the micropore size distribution of the Sipowder compacts was determ...

OBJECTIVES To review the most relevant articles regarding the technical aspects of inhalation therapy, inhalers currently available, and especially major advances in inhalation therapy in pediatrics. SOURCES Articles of MEDLINE database from 1983 were reviewed, in addition to book chapters, and the most important studies were selected according to the criteria established for this article. ...

Dry powder inhaler (DPI) is a dosage form for delivering fi ne drug powders to the respiratory tract. Particle size and size distribution, proportion of fi nes, particle shape, particle surface roughness, fl ow rate and adhesion force have been reported to affect the aerosolization process. Several mechanisms for particle dispersion in DPI have been considered; a proposed mechanism to explain t...

The objectives of this work were (i) to validate electrical zone sensing and laser diffraction for the analysis of primary particle size in the case of inhalation dry powders and (ii) to study the influence of the aggregation state of the powder on the sizing techniques. Free-flowing dry powders were prepared by spray-drying with a combination of albumin, lactose, and dipalmitoylphosphatidylcho...

The objective of this paper was to gain an understanding of the mixing and characterization of nanosized powders. Three different nanosized material systems were selected based on their physical and chemical properties. Mixing experiments of the selected nanopowders were performed using a variety of environmentally friendly dry powder processing devices and the rapid expansion of supercritical ...