Clinical trials incorporating treatment selection at pre-specified interim analyses allow to integrate two clinical studies into a single, confirmatory study. In an adaptive interim analysis, treatment arms are selected based on interim data as well as external information. The specific selection rule does not need to be pre-specified in advance in order to control the multiple type I error rat...

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BACKGROUND Increased oxidative stress is strongly implicated in bipolar disorder (BD), where protein oxidation, lipid peroxidation and oxidative damage to DNA have been consistently reported. High levels of dopamine (DA) in mania are also well-recognized in patients with BD, and DA produces reactive oxygen species and electron-deficient quinones that can oxidize proteins when it is metabolized....

In a one-way analysis of variance model, robust versions based on R-estimators are proposed for single-step multiple comparisons procedures discussed by Tukey (1953), Dunnett (1955), and Scheffé (1953). The robust procedures are two methods based on joint ranks and pairwise ranks. It is shown that the two methods are asymptotically equivalent. Although we fail to construct simultaneous tests ba...

Abstrucr; We address the problem of sample size determination for step-down multiple comparison procedures (MCP’s) for two nonhierarchical families orthogonal contrasts and comparisons with a control, in order to guarantee a specified requirement on their power. The results for the corresponding single-step MCP’s are obtained as special cases. Numerical calculations of the sample sizes to guara...

Investigating differences between means of more than two groups or experimental conditions is a routine research question addressed in biology. In order to assess differences statistically, multiple comparison procedures are applied. The most prominent procedures of this type, the Dunnett and Tukey-Kramer test, control the probability of reporting at least one false positive result when the dat...

s | 49 Aims: This project aims to assess whether systemic treatment with ketamine may improve the behavioural response in an animal model of a treatment resistant condition. Methods: Male Sprague-Dawley rats received subcutaneous injections of ACTH (100ug/rat/day) or vehicle during 14 days. On the 14th day the animals were exposed to the pre-test session of forced swim (FST) and after 24h they ...

s | 49 Aims: This project aims to assess whether systemic treatment with ketamine may improve the behavioural response in an animal model of a treatment resistant condition. Methods: Male Sprague-Dawley rats received subcutaneous injections of ACTH (100ug/rat/day) or vehicle during 14 days. On the 14th day the animals were exposed to the pre-test session of forced swim (FST) and after 24h they ...