background: interferon beta-la and -1b have been increasingly used for the treatment of multiple sclerosis (ms). the most frequent systemic adverse effects are flu-like symptoms. laboratory abnormalities include asymptomatic leukopenia and elevated hepatic transaminases. myelodysplastic syndrome (mds) refers to a spectrum of hematological disorders which can occur in different situations. sever...

Recent genetic analyses of large populations have revealed that somatic mutations in hematopoietic cells leading to clonal expansion are commonly acquired during human aging. Clonally restricted hematopoiesis is associated with an increased risk of subsequent diagnosis of myeloid or lymphoid neoplasia and increased all-cause mortality. Although myelodysplastic syndromes (MDS) are defined by cyt...

Anemia is common in hypothyroidism and is considered to be an adjustment to a decreased basal metabolism. It is characterized by reticulopenia, erythroid hypoplasia, and a decreased level of endogenous erythropoietin. It is possible that the thyroid insufficiency, and the consequent arrested hematopoiesis, hinder or prevent the fullblown bone marrow dysplastic features of MDS from manifesting. ...

BACKGROUND According to WHO 2008 guidelines, the required percentage of cells manifesting dysplasia in the bone marrow to qualify as significant is 10% or over in one or more hematopoietic cell lineages, but this threshold is controversial. No 'normal' values have been established. Therefore, we investigated dyshematopoiesis in bone marrow aspirate squash preparations of 120 healthy bone marrow...

Myelodysplastic syndrome (MDS) is a set of clonal bone marrow diseases in children that are characterised by peripheral cytopenia, dysplastic alterations the marrow, and inefficient hematopoiesis. MDS uncommon children, with just 1-4 occurrences per million afflicted. Adults, particularly elderly, more susceptible to disease. Some hereditary disorders, such as Fanconi's anaemia, Shwachman's, Do...

Myelodysplastic syndromes (MDS) are hematopoietic stem cell disorders characterized by dysplastic, ineffective, clonal and neoplastic hematopoiesis. MDS represent a complex hematological problem: differences in disease presentation, progression and outcome have necessitated the use of classification systems to improve diagnosis, prognostication, and treatment selection. However, since a single ...

Myelodysplastic syndrome is a closely related group of acquired bone marrow disorders characterized by ineffective and dysplastic hematopoiesis. These clonal disorders frequently progress to acute leukemia. Acute myelomonocytic leukemia with eosinophilia is characterized by an increase in abnormal eosinophils in the bone marrow, relatively good clinical course and inv (16) chromosomal abnormali...