نتایج جستجو برای: e2f1

تعداد نتایج: 1798  

Cheraghi SH, Malekinejad H Razi M

Background: Zearalenone (ZEA) is known as a nonsteroidal oestrogenic mycotoxin produced by different species of Fusarium fungi. ZEA is known for its competitive effects with the natural 17-β estradiol to bind with the specific binding sites of the estrogen receptors (Ers). On the other hand, the cyclin family (especially cyclin D1) and E2F1 genes are the checkpoint genes involved in cell cycle....

Journal: :iranian journal of basic medical sciences 0
zahra nazari department of animal sciences, faculty of biological sciences, kharazmi university, tehran, iran mohammad nabiuni department of cell and molecular biology, faculty of biological sciences, kharazmi university, tehran, iran mohsen saeidi stem cell research center, faculty of medicine, golestan university of medical sciences, gorgan, iran mohammad jafar golalipour gorgan congenital malformations research center, depatment of anatomical sciences, golestan university of medical sciences, gorgan, iran

objective(s): the link between a hyperglycemic intrauterine environment and the development of diabetes later in life has been observed in offspring exposed to gestational diabetes mellitus (gdm), but the underlying mechanisms for this phenomenon are still not clear. reduced β-cells mass is a determinant in the development of diabetes (type 1 and type 2 diabetes). some recent studies have provi...

Journal: :molecular and biochemical diagnosis (journal) 2014
seyed alireza mesbah namin cagatay gunes

background and aims: the e2f family of transcription factors is encoded by at least eight genes, e2f1-8. these proteins are important targets of the retinoblastoma protein (rb) contributed in regulation of transcription, cell cycle and apoptosis. the aim of this study was to investigate the expression levels of e2f protein family including e2f1, e2f2, e2f7, e2f8 and rb1 in the lineage negative ...

2017
Xiu-Bo Sang Zhi-Hong Zong Li-Li Wang Dan-Dan Wu Shuo Chen Bo-Liang Liu Yang Zhao

E2F1 (E2F transcription factor 1) can act as a tumor suppressor or oncogene. We report the molecular mechanism of E2F1 in ovarian carcinoma tumorigenesis and progression. E2F1 expression levels in ovarian carcinoma tissue were examined by immunohistochemistry. After E2F1 plasmid transfection and E2F1-microRNA-519d (miR-519d)/si-RhoC (Ras homolog gene family member C) co-transfection, ovarian ca...

Objective(s): The link between a hyperglycemic intrauterine environment and the development of diabetes later in life has been observed in offspring exposed to gestational diabetes mellitus (GDM), but the underlying mechanisms for this phenomenon are still not clear. Reduced β-cells mass is a determinant in the development of diabetes (type 1 and type 2 diabetes). Some recent studies have provi...

Journal: :Molecular cancer research : MCR 2010
Berta Ben Shachar Orit Feldstein Dalia Hacohen Doron Ginsberg

The E2F1 transcription factor is a critical downstream target of the tumor suppressor RB. When activated, E2F1 can induce cell proliferation and/or apoptosis. In addition, E2F1 overexpression sensitizes cancer cells to chemotherapeutic drugs. In a screen for genes that are regulated synergistically by E2F1 and chemotherapy in cancer cells, we identified the proapoptotic tumor suppressor gene ma...

Journal: :Journal of receptor and signal transduction research 2011
Qi Xie Yujie Bai Junbing Wu Yu Sun Yadong Wang Ye Zhang Pinchao Mei Zengqiang Yuan

E2F1 promotes DNA damage-induced apoptosis and the post-translational modifications of E2F1 play an important role in the regulation of E2F1-mediated cell death. Here, we found that Set9 and LSD1 regulate E2F1-mediated apoptosis upon DNA damage. Set9 methylates E2F1 at lysine 185, a conserved residue in the DNA-binding domain of E2F family proteins. The methylation of E2F1 by Set9 leads to the ...

Journal: :The Journal of biological chemistry 2004
Bing Wang Kang Liu Fang-Tsyr Lin Weei-Chin Lin

Genotoxic stress triggers apoptosis through multiple signaling pathways. Recent studies have demonstrated a specific induction of E2F1 accumulation and a role for E2F1 in apoptosis upon DNA damage. Induction of E2F1 is mediated by phosphorylation events that are dependent on DNA damage-responsive protein kinases, such as ATM. How ATM phosphorylation leads to E2F1 stabilization is unknown. We no...

2014
Zhonglei Lu Frederick Bauzon Hao Fu Jinhua Cui Hongling Zhao Keiko Nakayama Keiich I. Nakayama Liang Zhu

One mechanism of tumour suppression by pRb is repressing E2F1. Hence, E2f1 deletion diminishes tumorigenesis following Rb1 loss. However, E2F1 promotes both proliferation and apoptosis. It therefore remains unclear how de-repressed E2F1 promotes tumorigenesis. Another mechanism of pRb function is repressing Skp2 to elevate p27 to arrest proliferation. However, Skp2 deletion induced apoptosis, n...

Journal: :Journal of microbiology and biotechnology 2014
Hyun Hee Lee Se-Ra Lee Sun-Hee Leem

The transcription factor E2F1 is active during G1 to S transition and is involved in the cell cycle and progression. A recent study reported that increased E2F1 is associated with DNA damage and tumor development in several tissues using transgenic models. Here, we show that E2F1 expression is regulated by tristetraprolin (TTP) in prostate cancer. Overexpression of TTP decreased the stability o...

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