Lysine 48 (K48)-polyubiquitination is the predominant mechanism for mediating selective protein degradation, but the underlying molecular basis of selecting ubiquitin (Ub) K48 for linkage-specific chain synthesis remains elusive. Here, we present biochemical, structural, and cell-based evidence demonstrating a pivotal role for the Ub Y59-E51 loop in supporting K48-polyubiquitination. This loop ...

We have analyzed the genome of the domestic chicken for the presence of genetic sequences related to the envelope protein-encoding genes of avian sarcoma/leukosis retroviruses to determine the organization, structure, potential functionality, and distribution of such sequences. We have previously identified in the genus Gallus an extensive group of endogenous avian retroviruses termed EAV-0. So...

Article history: Received 8 February 2010 Available online 11 February 2010 JEL classification: D50 D51 D53 D61 E40 E50 E51 E52 E58

To improve the thermal and mechanical properties of epoxy resins, epoxy-functionalized POSS (E-POSS) glass fiber (GF) were used to reinforce resin (E51) composites. The tensile, thermo-mechanical, fractured, tests carried out characterize these hybrid materials. results show that E-POSS GF could significantly resins due high crosslink density matrix synergistic interaction between resin, E-POSS...

These include: References http://jmg.bmjjournals.com/cgi/content/full/39/9/e51#BIBL This article cites 20 articles, 1 of which can be accessed free at: Rapid responses http://jmg.bmjjournals.com/cgi/eletter-submit/39/9/e51 You can respond to this article at: service Email alerting top right corner of the article Receive free email alerts when new articles cite this article sign up in the box at...

We investigate the destruction of dust grains by sputtering in the high-velocity interstellar shocks driven by supernovae (SNe) in the early universe to reveal the dependence of the time-scale of dust destruction on the gas density nH,0 in the interstellar medium (ISM) as well as on the progenitor mass Mpr and explosion energy E51 of SN. The sputtering yields for the combinations of dust and io...

It is shown that, by allowing a transmutation between a boson and a fermion, the system with both bosons and fermions will have the statistical distribution function of an anyon. *E-mail: [email protected] Physical Review E51 (1995) 3729

This paper investigates how variations in macroeconomic uncertainty distort commercial banks’ allocation of loanable funds by analyzing the dispersion of banks’ total loan-to-asset ratios over a quartercentury period. JEL: C22, C23, D81, E51.

Human immunodeficiency virus (HIV-1) enters target cells by binding its gp120 exterior envelope glycoprotein to CD4 and one of the chemokine receptors, CCR5 or CXCR4. CD4-induced (CD4i) antibodies bind gp120 more efficiently after CD4 binding and block the interaction with the chemokine receptor. Examples of CD4i antibodies are limited, and the prototypes of the CD4i antibodies exhibit only wea...