how to cite this article: karimzadeh p, jafari n, nejad biglari hb, jabbehdari s, alizadeh m, alizadeh gh, nejad biglari hm, sanii s. the clinical features and diagnosis of adrenoleukodystrophy: a case series of iranian family. iran j child neurol. winter 2016; 10(1):61-64. abstract objective adrenoleukodystrophy disorder is one of the x-linked genetic disorders caused by the myelin sheath brea...

how to cite this article: karimzadeh p. approach to neurometabolic diseases from a pediatric neurological point of view. iran j child neurol. 2015 winter;9(1): 1-16.   abstract objective neurometabolic disorders are an important group of diseases that mostly are presented in newborns and infants. neurological manifestations are the prominent signs and symptoms in this group of diseases. seizure...

how to cite this article: karimzadeh p, jafari n, alai mr, jabbehdari s, ahmad abadi f, nejadbiglari h. homocystinuria: diagnosis and neuroimaging findings - of iranian pediatric patients. iran j child neurol. 2015 winter;9(1):94-98. abstract objective homocystinuria is a neurometabolic diseases characterized by symptoms include neurodevelopmental delay, lens dislocation, long limbs and thrombo...

calcineurin (can) is a ca2+/calmodulin (ca2+/cam)-dependent serine/threonine protein phosphatase expressed in most mammalian tissues but found at higher concentration in brain. in the last decade there have been a steadily increasing number of studies identifying neuronal can as a primary suspect in neuronal vulnerability, synapse loss, dendritic atrophy, synaptic dysfunction and neuroinflammat...

conclusions both task-related and resting fmri techniques have the potential to detect early brain dysfunction related to ad. however, the use of fmri in ad populations thus far has been limited to a relatively small number of research groups. results bold fmri is considered to reflect the joined synaptic activity of neurons through mri signal changes because of alterations in blood flow, blood...

introduction: newborn hearing screening leads to the early detection of hearing impairment. the aim of screening is to decrease or remove the effect of hearing impairment on development of speech and language by timely diagnosis and effective treatment. a number of risk factors lead to delayed start of decreased hearing ability including: 1. congenital infection with cytomegalovirus  (cmv) viru...

how to cite this article: najafi r, hashemipour m, mostofizadeh n, ghazavi mr, nasiri j, shahsanai a, famori f, najafi f, moafi m. demographic and clinical findings in pediatric patients affected by organic acidemia. iran j child neurol. spring 2016; 10(2): 74-81. abstract objective metabolic disorders, which involve many different organs, can be ascribed to enzyme deficiency or dysfunction and...

cell free dna (cfdna) is a genetic biomarker that is present in serum or plasma in high concentration in many types of cancer. identification of circu-lating cancer related dna molecules in serum or plasma is a non-invasive tool for early diagnosis and prognosis in many cancer patients. for this review, study selection and data extraction were performed by the authors. detection of point mutati...

breast cancer is the most important and prevalent cancer in women that can be managed if detected in the early stages. recently, there has been much focus on the use of epigenetic changes such as dna methylation in early detection of cancer. as recent research has put forth dok7 cpg island methylation as an epimarker, in the present study, using a quantification method, a cohort of iranian spor...

background: spontaneous preterm labor is one of the common obstetrics problems causing several physical, psychological and economical outcomes. although due to these outcomes and the efficacy of cares for decreasing them, preterm labor screening is cost-effective and it is still one of the challenging issues in obstetrics. objective: in this study preterm labor screening by using cervical trans...