نتایج جستجو برای: efrapeptins
تعداد نتایج: 7 فیلتر نتایج به سال:
Efrapeptins are a group of microheterogeneous polypeptide antibiotics produced by the fungus Tolypocladium niveum, which are potent inhibitors of mitochondrial F1-ATPase. Efrapeptins contain an unusual 1,5-diazabicyclo[4:3:0]nonene (DBN) residue at the C-terminus. This study is driven by the hypothesis that the DBN residue could, in principle, arise by oxidative cyclization of a spermidine moie...
the entomopathogenic-fungus-life cycle is associated with the synthesis and secretion of a number of toxic metabolites, including extracellular enzymes and the low-molecular weight compound (toxin). the potential for a successful pathogen relies on the ability to overcome the various host-defence systems. interaction between the fungus, tolypocla-dium (deuteromycetes), its secondary metabolite,...
Malaria caused by Plasmodium falciparum is a major public health problem in the developing countries of the world. Clinical treatment of malaria has become complicated due to the occurrence of infections caused by drug resistant parasites. Secondary metabolites from fungi are an attractive source of chemotherapeutic agents. This work reports the isolation and in vitro antiplasmodial activities ...
Extracellular ATP synthesis on human umbilical vein endothelial cells (HUVECs) was examined, and it was found that HUVECs possess high ATP synthesis activity on the cell surface. Extracellular ATP generation was detected within 5 s after addition of ADP and inorganic phosphate and reached a maximal level at 15 s. This type of ATP synthesis was almost completely inhibited by mitochondrial H(+)-A...
The use of electrospray ionization MS to determine the structure of glycans in intact glycoproteins.
and VIIIb (I. M. Fearnley, unpublished work), and the cytochrome bc, subunit IX [16], have been recorded satisfactorily in conventional solvents containing acetonitrile or methanol, and in some cases in chloroform/methanol also [5]. However, it is not possible to record spectra of the large proteolipids such as ND2 and ATPase6 in solvents based on acetonitrile or methanol, as large hydrophobic ...
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