Antitumor effectiveness of human leukocyte interferon alpha (IFN-a) was assessed in combination with electrotherapy. Subcutaneous fibrosarcoma SA-I tumors were treated with IFN-a for five consecutive days. The results indicate that IFN-a given either locally (peritumorally) or systemically (intraperitoneally) as a single treatment has moderate antitumor effect. In order to potentiate its effect...

Electrotherapy was investigated for its ability to increase the responsiveness of murine tumors to bleomycin treatment. Mice bearing fibrosarcoma were treated with 250 micrograms bleomycin and then with 0.6 mA direct current (DC) for 60 min. Antitumor effects of single treatments were moderate with bleomycin, but significant with electrotherapy. Combined treatment with bleomycin followed by ele...

Electrotherapy by low level direct current has been demonstrated to have antitumor effects in different murine tumor models and in clinics. Electrotherapy in "field" configuration, where electrodes are placed subcutaneously outside of the tumor in a way that tumor lies in between the electrodes, was performed in immunodeficient nude and immunocompetent mice. Electrotherapy was much more effecti...

Anti-tumour effects of direct current electrotherapy are attributed to different mechanisms depending on the electrode configuration and on the parameters of electric current. The effects mostly arise from the electrochemical products of electrolysis. Direct toxicity of these products to tumour tissue is, however, not a plausible explanation for the observed tumour growth retardation in the cas...

Electrotherapy with low-level direct current has been suggested as an effective regional cancer treatment. A great variety of electrode materials, their placement with respect to tumor (i.e. electrode configurations) current levels and therapeutic schedules have been employed to date. In our paper the impact of electrode materials and configurations was studied, employing the same treatment par...

A single-shot electrotherapy with 0,6 rnA direct current for 60 minutes delivered via two needle electrodes placed subcutaneously on opposite sides of a tumor induced statistically significant tumor growth delay in SA-l and LPB murine fibrosarcoma tumor models, A prolonged vascular occlusion is indicated by the results of staining tumors with a Patent Blue dye in the SA-l tumor model immediatel...

Electrotherapy with low-level direct electric current has been proved to be an effective local treatment of solid tumours. In the presented study an attempt was made to evaluate the effect of a single treatment with electrotherapy on blood perfusion of solid subcutaneous fibrosarcoma Sa-1 tumours in A/J mice. The tissue-staining method with Patent blue-violet dye, the rubidium extraction techni...

Electrotherapy with low-level direct current (DC) can induce antitumor effects in various tumor models. Applied in combination with certain anticancer drugs, it can significantly increase their effectiveness. It has been suggested that the demonstrated effects of electrotherapy arise from its modification of tumor blood flow. The effect of such treatment on blood perfusion of solid subcutaneous...

Direct current electrotherapy was demonstrated to be an effective and relatively inexpensive local treatment of murine solid subcutaneous tumours. The insufficient knowledge of the mechanisms involved hinders its more extensive use in clinical oncology. Attempts were made to establish the correlation between the effectiveness of electrotherapy and deposition of the electrode material in the tum...