objective: the greatest challenge in cancer gene therapy is to achieve the high specificity and efficiency in targeting of cancer cells. because the goal of cancer gene therapy is to eradicate cancer cells, many therapeutic genes could be detrimental if unintentionally expressed in normal cells. using promoter of the genes which are expressed specifically in cancer cells or have much more expre...

purpose : to assess and to compare stromal and endothelial changes at the cellular level in patients who had photorefractive keratectomy (prk) and laser in situ keratomileusis (lasik) using in vivo confocal microscopy methods : in this semiexperimental study, 32 eyes of 16 patients (4 males and 12 females) with low to moderate myopia [-1.00 to -4.50 diopters (d)] or low to moderate myopic astig...

The integrity of innermost layer the cornea, corneal endothelium, is key to sustaining transparency. Therefore, disease or injury causing loss damage endothelial cell population may threaten vision. Transplantation tissue standard treatment used replace malfunctioning cells. However, this surgery dependent upon donor tissue, which limited in supply. Hence, engineers have attempted construct alt...

Endothelial cells form a subtle monolayer covering the inner surface of the vascular tree. This unique localization allows them to integrate physical and neurohumoral signals from the blood and surrounding tissues to regulate vascular tone, cellular adhesion, inflammation, smooth muscle phenotype and proliferation as well as thromboresistance. Alterations of endothelial atheroprotective functio...

Although the etiology of varicose veins remains unknown, recent studies have focused on endothelial cell integrity and function because the endothelium regulates vessel tone and synthesizes many pro- and anti-inflammatory factors. The aim of this study was to investigate the evidence involving the endothelium in the development of varicose vein disease. In addition, tissue remodeling was invest...

Aim: In this study, we investigated the immune activity of Sox-9 and Cited-1 in women with placenta accreta. Material Methods: 20 healthy accreta were processed for routine histological tissue processing. Placentals samples dissected fixed 10% formaldehyde solution. Samples embedded paraffin blocks. Clinical biochemical parameters recorded. Placental sections cut from blocks stained immunostain...

atropine has been used to block cholinergic neurotransmission in basic research. large doses of atropine cause vasodilation of the blood vessels in the skin. this effect is apparently unconnected with the antimuscarinic activity of atropine and seems to be due to a direct action on the blood vessels. it has been suggested that atropine blocks muscarinic receptors at low doses and it induces the...

The eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) formulation with a ratio of 6:1 is potent stimulator the endothelial formation nitric oxide (NO). aim study was to investigate whether nanoencapsulation EPA:DHA followed by coating gum increases its biological activity. Vascular reactivity assessed using porcine coronary artery rings, NO in cultured cells (ECs) DAF-FM indirectly platelet...