background: the objective of this study is to develop a new animal model based on signaling pathways to understand the pathophysiology, therapy of depression, and to investigate the antidepressant activity of enicostemma littorale which is not yet established. methods: animal models of depression were raised by physical methods and administration of methyl isobutyl ketone (100 mg/kg b.w., i.p.,...

Enicostemma axillare (Lam.) Raynal, syn. E.littorale Blume family Gentinaceae, is a perennial herb found throughout the greater part of India. Locally it is known as chota chirayita and used in indigenous medicines in the treatment of fevers and as bitter tonic and forms hypoglycemic marketed formulations. Hence, this study was undertaken to determine the phytochemical studies and antioxidant a...

Glycoconjugates [protein bound hexose, protein bound hexosamine, total sialic acid and fucose] play a pivotal role in neoplastic transformation if they are abnormally expressed. The protective effect of Enicostemma littorale leaves on cell surface abnormalities was analyzed by measuring the status of the above said glycoconjugates during 7,12dimethylbenz(a) anthracene (DMBA) induced hamster buc...

Enicostemma littorale Blume is a medicinal plant commonly called as whitehead. Traditionally, the plant is used in the treatment of large number of human ailments such as in hypoglycemic, lowering the blood glucose level, as a potent anti-diabetic and antioxidant activity. Currently, the scientific research is going on to prove its medicinal value. Hence, to evaluate the phytoconstituents and t...