The whole-genome sequences of seven fatal enterovirus 71 (EV71) strains, isolated in southern China, in 2014, were determined. The complete genome sequences of these strains displayed close relationships to native EV71 strains and showed 94.2% to 99.8% identity to each other. All of these strains were assigned to subgenotype C4a based on phylogenetic analysis of the VP1 gene.

INTRODUCTION In Taiwan, severe enteroviral infections must be reported to the government within 24 hours to ensure that severe enterovirus 71 (EV71) infections can be detected early. The objective of this research was to ascertain whether over-reporting is a problem in mandatory disease-reporting systems. METHODOLOGY A multiyear cross-sectional study methodology was applied based on secondary...

The full-length genome sequence of a human enterovirus 71 (EV71) strain (EV71/CZTN01/CHN/2017) was isolated from a throat swab from a child in Changzhou, China, in 2017. According to the phylogenetic analyses, the full-genome sequence in this study belongs to sub-subgenotype C4a.

Outbreaks of human enterovirus 71 (EV-71) in Asia are related to high illness and death rates among children. To gain insight into the potential threat for the population of Europe, we determined the neutralizing activity in intravenous immunoglobulin (IVIg) batches and individual serum samples from donors in the Netherlands against EV-71 strains isolated in Europe and in Asia. All IVIg batches...

conclusions the c genotype should be considered as the prevalent ev71 circulating genotype in iran, particularly in cases of aseptic meningitis. patients and methods viral rna was extracted from 170 cerebrospinal fluid samples obtained from children aged under 8 years with a primary diagnosis of aseptic meningitis. specific ev71 pcr was conducted to identify the genotype of the detected ev71 vi...

introduction : viral meningitis is an inflammation of the leptomeninges as a manifestation of central nervous system (cns) infection, and more than 85% of viral meningitis cases are caused by non-polio enteroviruses. molecular methods such as polymerase chain reaction (pcr) are increasingly used to detect and type non-polio enteroviruses. here, we describe the impact of these viruses on aseptic...

Enterovirus 71 (EV71) frequently causes fatal infections in young children in Asia. In 2011, EV71 epidemics occurred in southern Vietnam. We conducted genetic and antigenic analysis of the EV71 isolates and found that 94% of them were genotype C4a related to two lineages circulating in China and 6% were genotype C5 which have circulated in Vietnam since 2003. Antigenic variants were not detecte...

Enterovirus 71 (EV-71) has been associated to cases of neurological disease in many countries including Brazil. This virus has now been reported from three of the five Brazilian regions. Our study relates the findings concerning to the first isolate of this virus in Northern region of Brazil. A 15-month old female patient, from the rural zone of the municipality of Santana do Araguaia in southe...

Enterovirus 71 (EV71) infection remains a public health problem at a global level, particularly in the Asia-Pacific region. The infection normally manifests as hand-foot-mouth disease; however, it is capable of developing into potentially fatal neurological complications. There is currently no approved vaccine or antiviral substance available for the prevention or treatment of EV71 infection. T...