نتایج جستجو برای: envelope domain iii ediii

تعداد نتایج: 689457  

Journal: :iranian journal of medical sciences 0
ajit kulkarni department of virology, haffkine institute for traning, research and testing, acharya donde marg, mumbai-400012 india rushil bhat department of virology, haffkine institute for traning, research and testing, acharya donde marg, mumbai-400012 india mansi malik department of zoonosis, haffkine institute for traning, research and testing, acharya donde marg, mumbai-400012 india suvarna sane national aids research institute, midc, bhosari, pune-411026 india sweta kothari department of virology, haffkine institute for traning, research and testing, acharya donde marg, mumbai-400012 india shashikant vaidya department of virology, haffkine institute for traning, research and testing, acharya donde marg, mumbai-400012 india

background: dengue is a global arboviral threat to humans; causing 390 million infections per year. the availability of safe and effective tetravalent dengue vaccine is a global requirement to prevent epidemics, morbidity, and mortality associated with it. methods: five experimental groups (6 mice per group) each of 5-week-old balb/c mice were immunized with vaccine and placebo (empty plasmid) ...

Journal: :Journal of virology 2012
Wahala M P B Wahala Claire Huang Siritorn Butrapet Laura J White Aravinda M de Silva

Humans develop polyclonal, serotype-specific neutralizing antibody responses after dengue virus (DENV) infection. Many mouse antibodies that neutralize DENV bind to the lateral ridge or A strand epitopes on domain III of the viral envelope (EDIII) protein. It has been assumed that these epitopes are also the main target of human neutralizing antibodies. Using recombinant dengue serotype 2 virus...

2012
Nicole J. Moreland Patricia Susanto Elfin Lim Moon Y. F. Tay Ravikumar Rajamanonmani Brendon J. Hanson Subhash G. Vasudevan

Domain III of the dengue virus envelope protein (EDIII, aa295-395) has an immunoglobulin fold and is the proposed receptor-binding domain of the virus. Previous studies have shown that monoclonal antibodies against EDIII can be neutralizing and have therapeutic potential. Here, cloned Fab-phage libraries of human and mouse origin were screened for DENV specific antibodies. Firstly, bacterially ...

2012
Upasana Arora Poornima Tyagi Sathyamangalam Swaminathan Navin Khanna

BACKGROUND Dengue is a global public health problem for which no drug or vaccine is available. Currently, there is increasing interest in developing non-replicating dengue vaccines based on a discrete antigenic domain of the major structural protein of dengue viruses (DENVs), known as envelope domain III (EDIII). The use of bio-nanoparticles consisting of recombinant viral structural polypeptid...

2016
Neha Kaushik Deepak Rohila Upasana Arora Rajendra Raut Urpo Lamminmäki Navin Khanna Gaurav Batra

BACKGROUND Dengue is a viral disease spread to humans by mosquitoes. Notably, there are four serotypes of dengue viruses (DENV) that places ~40 % of the global population at risk of infection. However, lack of a suitable drug or a preventive vaccine exacerbates the matter further. Envelope domain-III (EDIII) antigen of dengue virus (DENV) has garnered much attention as a promising vaccine candi...

2017
Xingcui Zhang Renyong Jia Haoyue Shen Mingshu Wang Zhongqiong Yin Anchun Cheng

Flaviviruses are enveloped, single-stranded RNA viruses that widely infect many animal species. The envelope protein, a structural protein of flavivirus, plays an important role in host cell viral infections. It is composed of three separate structural envelope domains I, II, and III (EDI, EDII, and EDIII). EDI is a structurally central domain of the envelope protein which stabilizes the overal...

2017
Denicar Lina Nascimento Fabris Maeda Milene Tavares Batista Lennon Ramos Pereira Mariana de Jesus Cintra Jaime Henrique Amorim Camila Mathias-Santos Sara Araújo Pereira Silvia Beatriz Boscardin Sandriana dos Ramos Silva Eliana L. Faquim-Mauro Vanessa Barbosa Silveira Danielle Bruna Leal Oliveira Stephen Albert Johnston Luís Carlos de Souza Ferreira Juliana Falcão Rodrigues

The heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli display adjuvant effects to coadministered antigens, leading to enhanced production of serum antibodies. Despite extensive knowledge of the adjuvant properties of LT derivatives, including in vitro-generated non-toxic mutant forms, little is known about the capacity of these adjuvants to modulate the epitope specificity of...

Journal: :The American journal of tropical medicine and hygiene 2008
Behzad Etemad Gaurav Batra Rajendra Raut Satinder Dahiya Saima Khanam Sathyamangalam Swaminathan Navin Khanna

There is currently no vaccine to prevent dengue (DEN) virus infection, which is caused by any one of four closely related serotypes, DEN-1, DEN-2, DEN-3, or DEN-4. A DEN vaccine must be tetravalent, because immunity to a single serotype does not offer cross-protection against the other serotypes. We have developed a novel tetravalent chimeric protein by fusing the receptor-binding envelope doma...

Journal: :Journal of Experimental Medicine 2021

Tick-borne encephalitis virus (TBEV) is an emerging human pathogen that causes potentially fatal disease with no specific treatment. Mouse monoclonal antibodies are protective against TBEV, but little known about the antibody response to infection. Here, we report on neutralizing TBEV in a cohort of infected and vaccinated individuals. Expanded clones memory B cells expressed closely related an...

2016
Jie Yang Lingyun Zou Yi Yang Jizhen Yuan Zhen Hu Hui Liu Huagang Peng Weilong Shang Xiaopeng Zhang Junmin Zhu Xiancai Rao

Damage to vascular endothelial cells (VECs) is a critical hallmark of hemorrhagic diseases caused by dengue virus (DENV). However, the precise molecular event involved in DENV binding and infection of VECs has yet to be clarified. In this study, vimentin (55 kDa) was identified to be involved in DENV-2 adsorption into VECs. This protein is located on the surface of VECs and interacts with DENV-...

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