Male rats were treated of with a diet supplemented daily by the synthetic food colour erythrosine (0.08 and 0.4 g/kg diet) for 30 days. Changes in mutagenic activities, as an index for evaluating of possible toxic effects, were monitored by measuring chromosomal aberrations of rat bone marrow, nucleic acids and total protein concentrations of rat liver and brain. The present study found that er...

The present work was designed to test the toxic impacts exerted by the colour additives erythrosine on the histology, ultrastructure and some serum liver function parameters in male albino rats. Erythrosine in a dose level equals 136 mg/kg bw was given orally to male albino rats for 4, 6 and 8 weeks. This caused time-dependent histological alterations in liver such as cytoplasmic vacuolization ...

Photodynamic Therapy (PDT) involves the administration of a tumor localizing photosensitizing agent, which upon activation with light of an appropriate wavelength leads to the destruction of the tumor cells. The aim of the present study was to determine the efficacy of erythrosine as a photosensitizer for the PDT of oral malignancies. The drug uptake kinetics of erythrosine in malignant (H357) ...

OBJECTIVES The purpose of this study was to evaluate the clinical plaque disclosing agent erythrosine as a photosensitizer in the photodynamic killing of the oral bacterium Streptococcus mutans grown as a biofilm. METHODS S. mutans biofilms of 200 microm thickness were grown in a constant-depth film fermenter. In addition to determining localization of the photosensitizer within biofilms usin...

The effect of erythrosine- and LED-mediated photodynamic therapy (PDT) on planktonic cultures and biofilms of Candida albicans and Candida dubliniensis was evaluated. Planktonic cultures of standardized suspensions (10(6)cells/mL) of C. albicans and C. dubliniensis were treated with erythrosine concentrations of 0.39-200 μM and LEDs in a 96-well microtiter plate. Biofilms formed by C. albicans ...

OBJECTIVES Recently, photodynamic therapy (PDT) has been introduced as a new modality in oral bacterial decontamination. Besides, the ability of laser irradiation in the presence of photosensitizing agent to lethal effect on oral bacteria is well documented. Current research aims to evaluate the effect of photodynamic killing of visible blue light in the presence of plaque disclosing agent eryt...

"Previous studies showed that repeated ingestion of erythrosine B [Red 3] (artificial food color) developed behavioral hyperactivity, but nothing is known about its single administration effect as well as the neurochemical (s) involvement. ... The degree of erythrosine-induced inhibition of both MA [motor activity] and brain regional serotonergic activity was dosage dependent. ... Altogether th...

Eleven organic synthetic dyes, currently or formerly used as food colours in Brazil, were tested to determine their effect on mitochondrial respiration in mitochondria isolated from rat liver and kidney. The compounds tested were: Erythrosine, Ponceau 4R, Allura Red, Sunset yellow, Tartrazine, Amaranth, Brilliant Blue, Blue, Fast Red E, Orange GGN and Scarlet GN. All food colours tested inhibit...

We hypothesize that iodine allergy is an immune response to iodinated self proteins produced in vivo from various iodine-containing chemicals. Since an antigenic determinant ofexperimental iodine allergy is diiodotyrosine (DIT), we designed low molecular weight DIT derivatives having provocative antigenicity without sensitizing immunogenicity, Tetraiododityrosine and hexaiodotrityrosine provoke...

PURPOSE The purpose of this study was to evaluate the effect of photodynamic therapy (PDT) using erythrosine and a green light emitting diode (LED) light source on biofilms of Aggregatibacter actinomycetemcomitans attached to resorbable blasted media (RBM) and sandblasted, large-grit, acid-etched (SLA) titanium surfaces in vitro. METHODS RBM and SLA disks were subdivided into four groups, inc...