results the mean ± sd of the clonic seizure threshold was 61.84 ± 8.53 in the group that received estradiol, while it was 71.70 ± 10.85 in the control group, 64.69 ± 3.23 in rats with laparotomy without removing the ovaries, 51.30 ± 6.84 in rats with laparotomy and removing the ovaries, 52.7 ± 7.18 in ovariectomized rats that received sesame oil as vehicle, and 59.2 ± 4.91, in the soy groups. t...

The aim of this study was to evidence the ability vegetable oil-based hybrid microparticles (HMP) be an efficient and safe drug delivery system after subcutaneous administration. HMP resulted from combination a thermostabilized emulsification process sol–gel chemistry. First all, castor oil successfully silylated by means (3-Isocyanatopropyl)trimethoxysilane in solvent-free catalyst-free condit...

results the results indicated that ghrelin significantly decreased thyroid hormone concentrations, whereas estradiol increased these concentrations. the simultaneous injection of ghrelin and estradiol significantly decreased the inhibitory effect of ghrelin on thyroid hormone concentrations (p < 0.05). conclusions according to the results of this study, both ghrelin and estradiol affect the con...

conclusions this study revealed that lod in females with pcos with a serum e2 > 40 pg/ml was sufficient and safe to trigger development of ovarian follicles followed by clinical pregnancy. results there was significant difference in the average starting time of ovulation and continuing spontaneous ovulation of cases with pcos with e2 levels > 40 pg/ml, compared with ones with e2 ≤ 40 pg/ml (p =...

The present study was carried out with the objective of evaluating, in castrated rats, utero trophic, hormonal and biochemical activities aqueous extracts Buchholzia coriacea (BC) Cogniauxia podolaena (CP) leaves. Each extract administered at dose 600 mg/Kg rats did not cause a significant change fresh weight/dry weight ratio uterus compared to given distilled water. However, those receiving 17...

Background Neuronal models of both familial and sporadic cases Alzheimer’s Disease (fAD/sAD) were generated from the human-derived induced pluripotent stem cells (iPSCs) AD patients. Using this in vitro cellular models, AD-like phenotypes was analyzed with or without 17β-estradiol, sex hormone that are supposed to be involved pathogenesis. Method 5 lines iPSCs comprised 1 healthy control, 2 fAD...

Background & Aims: Adult neurogenesis occurs in the two main areas of the brain of most mammalian species in; sub ventricular zone, and the dentate gyrus of the hippocampus. Many factors such as 17-β estradiol affect neurogenesis in the hippocampus. The aim of this study was to investigate the effect of exogenous 17-β estradiol on neurogenesis in the ovariectomized (OVX) mice. Materials & Meth...

background: the differential efficacy between long gnrh agonist with antagonist can partly be due to the preexisting differences in the early antral follicles before ovarian stimulation. objective: to compare the effect of pretreatment by estradiol with gnrh antagonist on antral follicular size coordination and basal hormone levels in gnrh antagonist protocol. materials and methods: on cycle da...