evidence-based principles (EBP) into the clinical decision-making process, I thought it would be worthwhile to assemble a special issue of JAAA concerned with how researcher-clinicians integrate evidence to create an effective treatment plan for their patients/clients. With this in mind, I asked the contributors to this special issue to “walk” the reader through the process of how they arrived ...

For the first time, technology exists to monitor the biological state of an organism at multiple levels. It is now possible to detect which genes are activated or deactivated when exposed to a chemical compound; to measure how these changes in gene expression cause the concentrations of cell metabolites to increase or decrease; to record whether these changes influence the over-all health of th...

The diffusion of innovation in the field software engineering is not well understood. This paper looks at how the legal field treats evidence in an attempt to identify ideas useful to both software engineering researchers and practitioners.

Nearly 2500 years ago, Hippocrates kicked off a revolution in healthcare by calling for the careful collection and recording of evidence about patients and their illnesses. This call—which first introduced the goal of sharing data among physicians to provide the best care possible for patients—established a foundation for the evolution of modern healthcare. Although 25 centuries have passed sin...

OBJECTIVE To analyze, from the examination of decisions issued by Brazilian courts, how Evidence-Based Medicine was applied and if it led to well-founded decisions, searching the best scientific knowledge. METHODS The decisions made by the Federal Courts were searched, with no time limits, at the website of the Federal Court Council, using the expression "Evidence-Based Medicine". With regard...

Contradictory statements about the non-steroidal anti-inflammatory drugs from the European Medicines Agency and the United States Food and Drug Administration have raised questions about whether regulatory decisions are evidence-based. For the selective COX-2 inhibitors, there are clear contraindications and warnings in Europe, but only a vaguely worded Black Box warning in the United States. A...

Medical practices, clinicai practice guideiines, ciinical performance measures and measurements, and a variety of health care-reiated administrative decisions, such as insurance coverage decisions, are claiming to be "evidence based" with increasing frequency, in this paper we examine the "evidence based" iabel; discuss how evidence ought to have been assembled, evaluated, and synthesized; and ...

Introduction: Today, due to the broad spectrum of pediatric cancers are treated by the chemotherapy drugs, but these drugs have side effects and gastrointestinal toxicity is the most prevalent. One of the main roles of nurses is to better health through patient education and care for him. Evidence-based nursing is a process during which the nurse can use the available research evidence, their c...